Zithromax Injection

  • Bacterial infections

Zithromax Injection Generic Name & Formulations

General Description

Azithromycin 500mg/vial; for IV infusion after reconstitution and dilution.

Pharmacological Class

Macrolide (azalide).

How Supplied

Tabs—30; Z-Pak (6 x 250mg tabs)—3; Tri-Pak (3 x 500mg tabs)—3; Susp 100mg/5mL—15mL; 200mg/5mL—15mL, 22.5mL, 30mL; Single Dose Packets—3, 10; Inj—10


Generic Availability


Zithromax Injection Indications


Susceptible infections including community-acquired pneumonia, pelvic inflammatory disease (PID).

Zithromax Injection Dosage and Administration


Give by IV infusion 1mg/mL over 3hrs or 2mg/mL over 1hr. ≥16yrs: Pneumonia: 500mg once daily for at least 2 days, switch to 500mg orally once daily, for a total of 7–10 days combined therapy. PID: 500mg once daily for 1–2 days, switch to 250mg orally once daily for a total of 7 days combined therapy.


<16yrs: not established.

Zithromax Injection Contraindications


Ketolide allergy. History of cholestatic jaundice/hepatic dysfunction associated with prior use.

Zithromax Injection Boxed Warnings

Not Applicable

Zithromax Injection Warnings/Precautions


Pneumonia: oral treatment is for mild, community-acquired cases suitable for outpatient therapy only. Discontinue if signs/symptoms of hepatitis occur. Known QT prolongation, proarrhythmic conditions, clinically significant bradycardia: avoid. Potential risk of cardiovascular death. Allergic symptoms may recur after initial successful symptomatic treatment. Myasthenia gravis. Hepatic or renal impairment. Elderly. Pregnancy. Nursing mothers: monitor infants.

Zithromax Injection Pharmacokinetics

See Literature

Zithromax Injection Interactions


Avoid concomitant aluminum- or magnesium-containing antacids. Monitor with digoxin, colchicine, phenytoin, warfarin. Monitor for azithromycin toxicity (eg, liver dysfunction, ototoxicity) with nelfinavir. Concomitant Class 1A (eg, quinidine, procainamide), or Class III (eg, dofetilide, amiodarone, sotalol) antiarrhythmics, or others known to prolong the QT interval: avoid.

Zithromax Injection Adverse Reactions

Adverse Reactions

Diarrhea, nausea, abdominal pain, vomiting, rash; hepatotoxicity, torsade de pointes (esp. elderly), C. difficile associated diarrhea; rare: allergic reactions (eg, angioedema, AGEP, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS), lab abnormalities.

Zithromax Injection Clinical Trials

See Literature

Zithromax Injection Note

Not Applicable

Zithromax Injection Patient Counseling

See Literature