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Zinacef Generic Name & Formulations
Legal Class
Rx
General Description
Cefuroxime (as sodium) 750mg, 1.5g; IM or IV inj; sodium content 2.4mEq/g.
Pharmacological Class
Cephalosporin.
How Supplied
Vials—10
Manufacturer
Generic Availability
YES
Zinacef Indications
Indications
Susceptible bacterial septicemia, lower respiratory or urinary tract, skin and skin structure, meningitis, bone and joint infections, gonorrhea. Surgical prophylaxis.
Zinacef Dosage and Administration
Adult
Use IV route for serious infections. Usual duration of therapy: 5–10 days. Uncomplicated UTIs, skin and skin structure, disseminated gonorrhea, or uncomplicated pneumonia: 750mg every 8 hours. Severe or complicated infections, bone and joint: 1.5g every 8 hours; life-threatening: 1.5g every 6 hours; meningitis: max 3g every 8 hours. Uncomplicated gonorrhea: 1.5g IM once (divide into 2 injections) with 1g oral probenecid. Prophylaxis: see full labeling. Renal dysfunction: CrCl 10–20mL/min: 750mg every 12 hours; CrCl <10mL/min: 750mg every 24 hours. Coincide a dose for end of dialysis.
Children
<3 months: not established. Give in equally divided doses. ≥3 months: usual range: 50–100mg/kg per day every 6–8 hours. Bone and joint: 150mg/kg per day every 8 hours. Meningitis: 200–240mg/kg per day IV every 6–8 hours. Renal dysfunction: reduce dose.
Zinacef Contraindications
Not Applicable
Zinacef Boxed Warnings
Not Applicable
Zinacef Warnings/Precautions
Warnings/Precautions
Penicillin allergy. Renal impairment, reduce dose. Monitor prothrombin time (in patients at risk), renal function. GI disease (esp. colitis). Elderly. Pregnancy (Cat.B). Nursing mothers.
Zinacef Pharmacokinetics
See Literature
Zinacef Interactions
Interactions
Avoid aminoglycosides, furosemide, ethacrynic acid, other nephrotoxic drugs. May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Potentiated by probenecid.
Zinacef Adverse Reactions
Adverse Reactions
Local reactions, blood dyscrasias, elevated liver enzymes; rarely: GI upset, rash (may be serious, eg, Stevens-Johnson syndrome), drug fever, anaphylaxis, interstitial nephritis, seizures, hearing loss in children treated for meningitis.
Zinacef Clinical Trials
See Literature
Zinacef Note
Not Applicable
Zinacef Patient Counseling
See Literature
