• Poisoning/overdose

Zimhi Generic Name & Formulations

General Description

Naloxone HCl 5mg/0.5mL; per syringe; soln for IM or SC inj.

Pharmacological Class

Opioid antagonist.

How Supplied

Single-dose prefilled syringe—1, 2


Generic Availability


Zimhi Indications


Emergency treatment of opioid overdose, as manifested by respiratory and/or CNS depression.

Zimhi Dosage and Administration

Adults and Children

<1yr: Pinch thigh muscle while administering; monitor inj site for residual needle parts and/or infection. ≥1yr: Inject IM or SC into the anterolateral aspect of the thigh (through clothing, if necessary) according to label instructions. All: may give additional doses (using a new syringe) every 2–3mins until desired response or emergency medical assistance available; continue surveillance. Repeated doses depending on amount, type, and route of administration of the opioid being antagonized may be required.

Zimhi Contraindications

Not Applicable

Zimhi Boxed Warnings

Not Applicable

Zimhi Warnings/Precautions


Not a substitute for emergency medical care. Risk of recurrent respiratory and CNS depression. Seek immediate emergency medical assistance after the first dose. Have other resuscitative measures available. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Post-op use in pre-existing cardiac disorders; monitor. Elderly. Pregnancy. Nursing mothers.

Zimhi Pharmacokinetics

See Literature

Zimhi Interactions


Caution with cardiotoxic drugs. Incomplete reversal of partial agonists or mixed agonists/antagonists (eg, buprenorphine, pentazocine); may require higher naloxone dose.

Zimhi Adverse Reactions

Adverse Reactions

Nausea, dizziness, lightheadedness, elevated bilirubin; precipitation of severe opioid withdrawal.

Zimhi Clinical Trials

See Literature

Zimhi Note

Not Applicable

Zimhi Patient Counseling

See Literature