• Rosacea

Zilxi Generic Name & Formulations

General Description

Minocycline (as HCl) 1.5%; foam; contains alcohol.

Pharmacological Class

Tetracycline antibiotic.

How Supplied


Generic Availability


Zilxi Indications


Inflammatory lesions of rosacea.

Limitations of Use

Not been evaluated in the treatment of infections.

Zilxi Dosage and Administration


Apply at the same time each day ≥1hr before bedtime. Apply a thin layer onto affected area(s) of the face; repeat as needed. Avoid bathing, showering or swimming for ≥1hr after application.


Not established.

Zilxi Contraindications

Not Applicable

Zilxi Boxed Warnings

Not Applicable

Zilxi Warnings/Precautions


Not for oral, ophthalmic, or intravaginal use. Monitor for visual disturbances prior to initiation. History of intracranial hypertension. Overweight women. Avoid sunlight or UV light; discontinue at 1st sign of sunburn. Discontinue if serious skin reactions (eg, Stevens Johnson syndrome, erythema multiforme, DRESS syndrome) or superinfection develop. Hepatic or renal impairment. Product is flammable. Pregnancy. Nursing mothers: not recommended.

Zilxi Pharmacokinetics

See Literature

Zilxi Interactions


Avoid concomitant penicillins, isotretinoin. May need to reduce concomitant anticoagulant dose. May interfere with fluorescence test.

Zilxi Adverse Reactions

Adverse Reactions

Diarrhea; teeth discoloration, delayed skeletal development, intracranial hypertension, CNS effects, C. difficile-associated diarrhea, increased BUN, hepatotoxicity, renal toxicity, photosensitivity, skin/hypersensitivity reactions (may be severe), hyperpigmentation, autoimmune syndromes (eg, lupus-like syndrome, serum sickness; discontinue if symptoms occur).

Zilxi Clinical Trials

See Literature

Zilxi Note

Not Applicable

Zilxi Patient Counseling

See Literature