Ziagen Generic Name & Formulations
Legal Class
Rx
General Description
Abacavir (as sulfate) 300mg; scored tabs.
Pharmacological Class
Nucleoside analogue (reverse transcriptase inhibitor).
See Also
How Supplied
Tabs—60; Soln—240mL
Manufacturer
Ziagen Indications
Indications
HIV-1 infection, in combination with other antiretroviral agents.
Ziagen Dosage and Administration
Adult
300mg twice daily or 600mg once daily. Mild hepatic impairment: 200mg twice daily (use oral soln for titration).
Children
<3mos: not established. ≥3mos (oral soln): 8mg/kg twice daily or 16mg/kg once daily; max 600mg daily. If able to swallow tabs: 14–<20kg: 300mg once daily or 150mg twice daily; ≥20–<25kg: 450mg once daily or 150mg in the AM and 300mg in the PM; ≥25kg: use Adult dose.
Ziagen Contraindications
Contraindications
Presence of HLA-B*5701 allele. Prior hypersensitivity reaction to abacavir (see full labeling). Moderate or severe hepatic impairment.
Ziagen Boxed Warnings
Boxed Warning
Hypersensitivity reactions.
Ziagen Warnings/Precautions
Warnings/Precautions
Screen for presence of HLA-B*5701 allele prior to starting therapy or reinitiation; if (+), abacavir is contraindicated. Discontinue immediately if hypersensitivity is suspected, regardless of HLA-B*5701 status and even when other diagnoses are possible. If hypersensitivity cannot be ruled out, do not restart. If stopped for reasons other than hypersensitivity, restart only if medical care can be readily accessed. Suspend if lactic acidosis or pronounced hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Possible risk of MI; minimize risk factors for coronary heart disease (eg, hypertension, hyperlipidemia, diabetes, smoking). Women. Obesity. Elderly. Pregnancy. Nursing mothers: not recommended.
Ziagen Pharmacokinetics
See Literature
Ziagen Interactions
Interactions
Potentiates riociguat. May be potentiated by ethanol. Antagonizes methadone.
Ziagen Adverse Reactions
Adverse Reactions
Nausea, vomiting, headache, malaise, fatigue, dreams/sleep disorders, diarrhea, fever, chills, rash (may be severe, eg, Stevens-Johnson), ear/nose/throat infections; hypersensitivity reactions (may be fatal), lactic acidosis, severe hepatomegaly with steatosis, immune reconstitution syndrome.
Ziagen Clinical Trials
See Literature
Ziagen Note
Notes
Register pregnant patients exposed to abacavir by calling (800) 258-4263.
Ziagen Patient Counseling
See Literature