Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Ziac Generic Name & Formulations
Legal Class
Rx
General Description
Bisoprolol (as fumarate), hydrochlorothiazide; 2.5mg/6.25mg, 5mg/6.25mg, 10mg/6.25mg; tabs.
Pharmacological Class
Cardioselective beta-blocker + diuretic.
How Supplied
Tabs 2.5mg/6.25mg, 5mg/6.25mg—100; 10mg/6.25mg—30
Manufacturer
Generic Availability
YES
Ziac Indications
Indications
Hypertension.
Ziac Dosage and Administration
Adult
Initially one 2.5mg/6.25mg tab once daily. Adjust at 14-day intervals; max two 10mg/6.25mg tabs (20mg bisoprolol + 12.5mg HCTZ) once daily.
Children
Not established.
Ziac Contraindications
Contraindications
Cardiogenic shock. Overt heart failure. 2nd- or 3rd-degree AV block. Marked sinus bradycardia. Anuria. Sulfonamide allergy.
Ziac Boxed Warnings
Not Applicable
Ziac Warnings/Precautions
Warnings/Precautions
CHF. Peripheral vascular disease. Bronchospastic disease. Surgery. Thyroid disease. Avoid abrupt cessation. Gout. Arrhythmia. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Discontinue if electrolyte disorders develop rapidly. Acute angle-closure glaucoma (with or without acute myopia and choroidal effusions). Diabetes. Hepatic or renal impairment. Pregnancy. Nursing mothers: not recommended.
Ziac Pharmacokinetics
See Literature
Ziac Interactions
Interactions
May potentiate other antihypertensives, reserpine, guanethidine, other catecholamine-depleting drugs, calcium channel blockers, antiarrhythmics, myocardial depressants, nondepolarizing muscle relaxants. Digitalis, lithium toxicity. Antagonized by rifampin, NSAIDs. Increased rebound hypertension with clonidine withdrawal. Adjust antidiabetic, antigout medications. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May block epinephrine. May interfere with parathyroid tests.
Ziac Adverse Reactions
Adverse Reactions
Dizziness, fatigue, cough, insomnia, diarrhea, muscle cramps, impotence; HCTZ: increased risk for non-melanoma skin cancer.
Ziac Clinical Trials
See Literature
Ziac Note
Not Applicable
Ziac Patient Counseling
See Literature
