• Hypertension

Ziac Generic Name & Formulations

General Description

Bisoprolol (as fumarate), hydrochlorothiazide; 2.5mg/6.25mg, 5mg/6.25mg, 10mg/6.25mg; tabs.

Pharmacological Class

Cardioselective beta-blocker + diuretic.

How Supplied

Tabs 2.5mg/6.25mg, 5mg/6.25mg—100; 10mg/6.25mg—30


Generic Availability


Ziac Indications



Ziac Dosage and Administration


Initially one 2.5mg/6.25mg tab once daily. Adjust at 14-day intervals; max two 10mg/6.25mg tabs (20mg bisoprolol + 12.5mg HCTZ) once daily.


Not established.

Ziac Contraindications


Cardiogenic shock. Overt heart failure. 2nd- or 3rd-degree AV block. Marked sinus bradycardia. Anuria. Sulfonamide allergy.

Ziac Boxed Warnings

Not Applicable

Ziac Warnings/Precautions


CHF. Peripheral vascular disease. Bronchospastic disease. Surgery. Thyroid disease. Avoid abrupt cessation. Gout. Arrhythmia. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Discontinue if electrolyte disorders develop rapidly. Acute angle-closure glaucoma (with or without acute myopia and choroidal effusions). Diabetes. Hepatic or renal impairment. Pregnancy. Nursing mothers: not recommended.

Ziac Pharmacokinetics

See Literature

Ziac Interactions


May potentiate other antihypertensives, reserpine, guanethidine, other catecholamine-depleting drugs, calcium channel blockers, antiarrhythmics, myocardial depressants, nondepolarizing muscle relaxants. Digitalis, lithium toxicity. Antagonized by rifampin, NSAIDs. Increased rebound hypertension with clonidine withdrawal. Adjust antidiabetic, antigout medications. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May block epinephrine. May interfere with parathyroid tests.

Ziac Adverse Reactions

Adverse Reactions

Dizziness, fatigue, cough, insomnia, diarrhea, muscle cramps, impotence; HCTZ: increased risk for non-melanoma skin cancer.

Ziac Clinical Trials

See Literature

Ziac Note

Not Applicable

Ziac Patient Counseling

See Literature