Zerbaxa Generic Name & Formulations
Ceftolozane, tazobactam; 1.5g/vial; pwd for IV infusion after reconstitution; preservative-free; contains sodium chloride 487mg/vial.
Cephalosporin + beta-lactamase inhibitor.
Susceptible complicated intra-abdominal infections (cIAI) in combination with metronidazole, complicated urinary tract infections (cUTI), including pyelonephritis, hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).
Zerbaxa Dosage and Administration
Give by IV infusion over 1hr. ≥18yrs (CrCl >50mL/min): cIAI: 1.5g every 8hrs for 4–14 days (with IV metronidazole 500mg every 8hrs); cUTI: 1.5g every 8hrs for 7 days; HABP/VABP: 3g every 8hrs for 8–14 days. Renal impairment: cIAI, cUTI (CrCl 30–50mL/min): 750mg every 8hrs; (CrCl 15–29mL/min): 375mg every 8hrs; ESRD on hemodialysis: 750mg loading dose, followed by 150mg maintenance dose every 8hrs for remainder of treatment (give on dialysis days). HABP/VABP (CrCl 30–50mL/min): 1.5g every 8hrs; (CrCl 15–29mL/min): 750mg every 8hrs; ESRD on hemodialysis: 2.25g loading dose, followed by 450mg maintenance dose every 8hrs for remainder of treatment (give on dialysis days).
<18yrs: not established (HABP/VABP). Give by IV infusion over 1hr. Birth–<18yrs (eGFR >50mL/min/1.73m2): cIAI: 30mg/kg every 8hrs for 5–14 days (with metronidazole); cUTI: 30mg/kg every 8hrs for 7–14 days. For patients >50kg: do not exceed a max dose of 1.5g. Renal impairment (eGFR ≤50mL/min/1.73m2): not recommended.
Cephalosporin, penicillin, or other beta-lactam allergy.
Zerbaxa Boxed Warnings
Discontinue if serious hypersensitivity reactions occur. Monitor CrCl at least daily in those with changing renal function and adjust dose. Renal impairment. Elderly. Pregnancy. Nursing mothers.
Zerbaxa Adverse Reactions
Nausea, diarrhea, headache, pyrexia, increased transaminases, renal impairment/failure; C. difficile-associated diarrhea, anaphylaxis; children: also thrombocytosis, leukopenia, abdominal pain, vomiting, anemia.
Zerbaxa Clinical Trials
Zerbaxa Patient Counseling