Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Zavzpret Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Nasal spray (single dose)—6 units
Manufacturer
Generic Availability
NO
Mechanism of Action
Zavegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist.
Zavzpret Indications
Indications
Acute treatment of migraine with or without aura.
Limitations of Use
Not for prevention of migraine.
Zavzpret Dosage and Administration
Adult
1 spray (10mg) in one nostril as needed. Max 10mg in 24hr period.
Children
Not established.
Zavzpret Contraindications
Not Applicable
Zavzpret Boxed Warnings
Not Applicable
Zavzpret Warnings/Precautions
Warnings/Precautions
Discontinue and treat if hypersensitivity reaction occurs. Severe hepatic impairment or renal impairment (CrCl <30mL/min): avoid. Pregnancy. Nursing mothers.
Zavzpret Pharmacokinetics
Absorption
Absolute bioavailability: ~5%.
Distribution
Plasma protein bound: ~90%.
Mean apparent volume of distribution: ~1774 L.
Elimination
Fecal (80%), renal (11%).
Half-life: 6.55 hours.
Mean apparent clearance: 266 L/h.
Zavzpret Interactions
Interactions
Avoid concomitant OATP1B3 or NTCP inhibitors or inducers. Avoid concomitant intranasal decongestants; if unavoidable, give ≥1hr after Zavzpret dose.
Zavzpret Adverse Reactions
Adverse Reactions
Taste disorders, nausea, nasal discomfort, vomiting; hypersensitivity reactions.
Zavzpret Clinical Trials
See Literature
Zavzpret Note
Not Applicable
Zavzpret Patient Counseling
See Literature
