• Seizure disorders

Zarontin Generic Name & Formulations

General Description

Ethosuximide 250mg; caps.

Pharmacological Class


See Also

How Supplied

Caps—100; Syrup—pt


Generic Availability

Caps, syrup (YES)

Zarontin Indications


Absence seizures.

Zarontin Dosage and Administration


Initially: 500mg daily. Increase every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses.


<3yrs: not established. 3–6yrs: initially 250mg daily. >6yrs: initially 500mg daily. Increase both every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses. Usual maintenance: 20mg/kg/day in divided doses.

Zarontin Contraindications

Not Applicable

Zarontin Boxed Warnings

Not Applicable

Zarontin Warnings/Precautions


Impaired hepatic or renal function. May precipitate tonic-clonic seizures. Discontinue at 1st sign of rash; consider alternative therapy if signs/symptoms of Stevens-Johnson syndrome occurs. Evaluate immediately if signs/symptoms of DRESS/multi-organ hypersensitivity develop; discontinue if no alternative etiology. Monitor for depression, suicidal ideation, unusual changes in mood/behavior. Monitor CBCs, kidney and liver function periodically. Change dose gradually. Pregnancy. Nursing mothers: not recommended.

Zarontin Pharmacokinetics

See Literature

Zarontin Interactions


Monitor phenytoin, phenobarbital, valproic acid, other AEDs.

Zarontin Adverse Reactions

Adverse Reactions

Blood dyscrasias, drowsiness, ataxia, dizziness, headache, GI upset, CNS and psychiatric effects, rash (may be fatal), SLE, DRESS, gingival hyperplasia.

Zarontin Clinical Trials

See Literature

Zarontin Note

Not Applicable

Zarontin Patient Counseling

See Literature