Zarontin Syrup

  • Seizure disorders

Zarontin Syrup Generic Name & Formulations

General Description

Ethosuximide 250mg/5mL; oral soln; raspberry flavor.

Pharmacological Class


See Also

How Supplied

Caps—100; Syrup—pt


Generic Availability

Caps, syrup (YES)

Zarontin Syrup Indications


Absence seizures.

Zarontin Syrup Dosage and Administration


Initially: 500mg daily. Increase every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses.


<3yrs: not established. 3–6yrs: initially 250mg daily. >6yrs: initially 500mg daily. Increase both every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses. Usual maintenance: 20mg/kg/day in divided doses.

Zarontin Syrup Contraindications

Not Applicable

Zarontin Syrup Boxed Warnings

Not Applicable

Zarontin Syrup Warnings/Precautions


Impaired hepatic or renal function. May precipitate tonic-clonic seizures. Discontinue at 1st sign of rash; consider alternative therapy if signs/symptoms of Stevens-Johnson syndrome occurs. Evaluate immediately if signs/symptoms of DRESS/multi-organ hypersensitivity develop; discontinue if no alternative etiology. Monitor for depression, suicidal ideation, unusual changes in mood/behavior. Monitor CBCs, kidney and liver function periodically. Change dose gradually. Pregnancy. Nursing mothers: not recommended.

Zarontin Syrup Pharmacokinetics

See Literature

Zarontin Syrup Interactions


Monitor phenytoin, phenobarbital, valproic acid, other AEDs.

Zarontin Syrup Adverse Reactions

Adverse Reactions

Blood dyscrasias, drowsiness, ataxia, dizziness, headache, GI upset, CNS and psychiatric effects, rash (may be fatal), SLE, DRESS, gingival hyperplasia.

Zarontin Syrup Clinical Trials

See Literature

Zarontin Syrup Note

Not Applicable

Zarontin Syrup Patient Counseling

See Literature