Zantac Injection

  • Hyperacidity, GERD, and ulcers

Zantac Injection Generic Name & Formulations

General Description

Ranitidine (as HCl) 25mg/mL; IM or IV inj; contains phenol.

Pharmacological Class

H2 blocker.

How Supplied

Tabs, syrup—contact supplier; Inj single dose (2mL)—10; Multidose (6mL)—1; Premixed (50mL)—24


Zantac Injection Indications


Hospitalized patients with pathological hypersecretory conditions, intractable duodenal ulcer. Short-term alternative to oral therapy.

Zantac Injection Dosage and Administration


>16yrs: 50mg every 6–8 hrs by IM inj, or intermittent IV bolus (dilute; give over 5mins), or intermittent IV (dilute; give over 15–20mins); usual max 400mg/day. Continuous IV infusion, or for Zollinger-Ellison: see full labeling. Renal impairment (CrCl <50mL/min): 50mg every 18–24hrs or more often if needed (intermittent only). Coincide a dose for end of hemodialysis.


<1month: not recommended. ≥1month–16yrs: Treatment of duodenal ulcer: 2–4mg/kg per day in divided doses every 6–8hrs; max 50mg every 6–8hrs.

Zantac Injection Contraindications

Not Applicable

Zantac Injection Boxed Warnings

Not Applicable

Zantac Injection Warnings/Precautions


History of acute porphyria: not recommended. Renal impairment: reduce dose. Hepatic dysfunction. Discontinue if hepatic disorders occur. Monitor SGPT if on high-dose IV therapy for ≥5 days. Pregnancy (Cat.B). Nursing mothers.

Zantac Injection Pharmacokinetics

See Literature

Zantac Injection Interactions


May increase triazolam, midazolam, glipizide, procainamide levels. May decrease ketoconazole, atazanavir, delaviridine, gefitnib levels. Monitor anticoagulants. May cause false (+) urine protein test with Multistix.

Zantac Injection Adverse Reactions

Adverse Reactions

Headache, GI disturbances, jaundice, hepatitis, rash; rare: CNS disturbances, arrhythmias, blurred vision, arthralgia, myalgia, inj site reactions, blood dyscrasias, anaphylaxis, angioneurotic edema, acute interstitial nephritis, bradycardia with rapid administration (IV); increased risk of pneumonia (see full labeling).

Zantac Injection Clinical Trials

See Literature

Zantac Injection Note

Not Applicable

Zantac Injection Patient Counseling

See Literature