Zanaflex Tablets

  • Muscle spasms

Zanaflex Tablets Generic Name & Formulations

General Description

Tizanidine HCl 4mg (quadrisecting score); tabs.

Pharmacological Class

Alpha-2 agonist.

How Supplied

Tabs, caps—150

Zanaflex Tablets Indications


Muscle spasticity (due to its short duration of action reserve for when relief is most important).

Zanaflex Tablets Dosage and Administration


Initially: usually 4mg, may increase by 2–4mg as needed every 6–8 hrs to a max of 3 doses in 24hrs; max 12mg/dose and 36mg/day. Renal impairment (CrCl <25mL/min): reduce dose. May sprinkle contents of capsules on applesauce (may affect absorption). Tabs and caps not bioequivalent under fed conditions. See full labeling.


Not established.

Zanaflex Tablets Contraindications


Concomitant fluvoxamine, ciprofloxacin.

Zanaflex Tablets Boxed Warnings

Not Applicable

Zanaflex Tablets Warnings/Precautions


Hepatic dysfunction. Monitor ophthalmic and liver function (aminotransferases at baseline, 1, 3, 6 months, then periodically) and for orthostatic hypotension. Renal dysfunction. Cardiovascular disease. Avoid abrupt cessation. Elderly. Labor & delivery. Pregnancy. Nursing mothers.

Zanaflex Tablets Pharmacokinetics

See Literature

Zanaflex Tablets Interactions


Avoid other α2-agonists (eg, clonidine). Hypotension possible with other antihypertensives. Avoid concomitant use with other CYP1A2 inhibitors (eg, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, other fluoroquinolones, oral contraceptives, acyclovir, ticlopidine, zileuton); if clinically necessary, use caution. May potentiate CNS depression with alcohol, baclofen, benzodiazepines, other CNS depressants.

Zanaflex Tablets Adverse Reactions

Adverse Reactions

Dry mouth, somnolence, asthenia, dizziness, UTI, constipation, liver injury or elevated liver enzymes, vomiting, speech disorder, blurred vision, dyskinesia, nervousness, pharyngitis, hypotension, bradycardia, hallucinations/psychosis.

Zanaflex Tablets Clinical Trials

See Literature

Zanaflex Tablets Note

Not Applicable

Zanaflex Tablets Patient Counseling

See Literature