Zanaflex Tablets Generic Name & Formulations
Tizanidine HCl 4mg (quadrisecting score); tabs.
Zanaflex Tablets Indications
Muscle spasticity (due to its short duration of action reserve for when relief is most important).
Zanaflex Tablets Dosage and Administration
Initially: usually 4mg, may increase by 2–4mg as needed every 6–8 hrs to a max of 3 doses in 24hrs; max 12mg/dose and 36mg/day. Renal impairment (CrCl <25mL/min): reduce dose. May sprinkle contents of capsules on applesauce (may affect absorption). Tabs and caps not bioequivalent under fed conditions. See full labeling.
Zanaflex Tablets Contraindications
Concomitant fluvoxamine, ciprofloxacin.
Zanaflex Tablets Boxed Warnings
Zanaflex Tablets Warnings/Precautions
Hepatic dysfunction. Monitor ophthalmic and liver function (aminotransferases at baseline, 1, 3, 6 months, then periodically) and for orthostatic hypotension. Renal dysfunction. Cardiovascular disease. Avoid abrupt cessation. Elderly. Labor & delivery. Pregnancy. Nursing mothers.
Zanaflex Tablets Pharmacokinetics
Zanaflex Tablets Interactions
Avoid other α2-agonists (eg, clonidine). Hypotension possible with other antihypertensives. Avoid concomitant use with other CYP1A2 inhibitors (eg, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, other fluoroquinolones, oral contraceptives, acyclovir, ticlopidine, zileuton); if clinically necessary, use caution. May potentiate CNS depression with alcohol, baclofen, benzodiazepines, other CNS depressants.
Zanaflex Tablets Adverse Reactions
Dry mouth, somnolence, asthenia, dizziness, UTI, constipation, liver injury or elevated liver enzymes, vomiting, speech disorder, blurred vision, dyskinesia, nervousness, pharyngitis, hypotension, bradycardia, hallucinations/psychosis.
Zanaflex Tablets Clinical Trials
Zanaflex Tablets Note
Zanaflex Tablets Patient Counseling