Zanaflex Capsules

  • Muscle spasms

Zanaflex Capsules Generic Name & Formulations

General Description

Tizanidine HCl 2mg, 4mg, 6mg; caps.

Pharmacological Class

Alpha-2 agonist.

See Also

How Supplied

Tabs, caps—150

Zanaflex Capsules Indications


Muscle spasticity (due to its short duration of action reserve for when relief is most important).

Zanaflex Capsules Dosage and Administration


Initially: usually 4mg, may increase by 2–4mg as needed every 6–8 hrs to a max of 3 doses in 24hrs; max 12mg/dose and 36mg/day. Renal impairment (CrCl <25mL/min): reduce dose. May sprinkle contents of capsules on applesauce (may affect absorption). Tabs and caps not bioequivalent under fed conditions. See full labeling.


Not established.

Zanaflex Capsules Contraindications


Concomitant fluvoxamine, ciprofloxacin.

Zanaflex Capsules Boxed Warnings

Not Applicable

Zanaflex Capsules Warnings/Precautions


Hepatic dysfunction. Monitor ophthalmic and liver function (aminotransferases at baseline, 1, 3, 6 months, then periodically) and for orthostatic hypotension. Renal dysfunction. Cardiovascular disease. Avoid abrupt cessation. Elderly. Labor & delivery. Pregnancy. Nursing mothers.

Zanaflex Capsules Pharmacokinetics

See Literature

Zanaflex Capsules Interactions


Avoid other α2-agonists (eg, clonidine). Hypotension possible with other antihypertensives. Avoid concomitant use with other CYP1A2 inhibitors (eg, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, other fluoroquinolones, oral contraceptives, acyclovir, ticlopidine, zileuton); if clinically necessary, use caution. May potentiate CNS depression with alcohol, baclofen, benzodiazepines, other CNS depressants.

Zanaflex Capsules Adverse Reactions

Adverse Reactions

Dry mouth, somnolence, asthenia, dizziness, UTI, constipation, liver injury or elevated liver enzymes, vomiting, speech disorder, blurred vision, dyskinesia, nervousness, pharyngitis, hypotension, bradycardia, hallucinations/psychosis.

Zanaflex Capsules Clinical Trials

See Literature

Zanaflex Capsules Note

Not Applicable

Zanaflex Capsules Patient Counseling

See Literature