Indications for: YUPELRI

Maintenance treatment of COPD.

Adult Dosage:

Administer by the orally inhaled route via standard jet nebulizer connected to an air compressor. Inhale 1 vial (175mcg) once daily (using a mouthpiece).

Children Dosage:

Not established.

YUPELRI Warnings/Precautions:

Do not initiate during acutely deteriorating or potentially life-threatening COPD episodes. Not for treating acute symptoms. ­Prescribe a short-acting β2-agonist for acute symptoms; monitor for increased need. Do not exceed recommended dose. Discontinue immediately and treat if paradoxical bronchospasm or immediate hypersensitivity reactions occur; use alternative therapy. Narrow-angle glaucoma. Urinary retention. Prostatic hyperplasia. Bladder-neck obstruction. Hepatic impairment: not recommended. Severe renal impairment: monitor. Pregnancy. Nursing mothers.

YUPELRI Classification:

Long-acting anticholinergic.

YUPELRI Interactions:

Additive effects with concomitant other anticholinergic-containing drugs; avoid. Concomitant OATP1B1 and OATP1B3 inhibitors (eg, rifampicin, cyclosporine): not recommended.

Adverse Reactions:

Cough, nasopharyngitis, upper respiratory tract infection, headache, back pain; paradoxical bronchospasm.

Generic Drug Availability:


How Supplied:

Vials (3mL)—7, 30

Pricing for YUPELRI

30 vials of 175mcg/3ml carton (Qty: 1)
Appx. price $1235