Yupelri Generic Name & Formulations
Legal Class
Rx
General Description
Revefenacin 175mcg/3mL; soln for inh.
Pharmacological Class
Long-acting anticholinergic.
How Supplied
Vials (3mL)—7, 30
Manufacturer
Generic Availability
NO
Yupelri Indications
Indications
Maintenance treatment of COPD.
Yupelri Dosage and Administration
Adult
Administer by the orally inhaled route via standard jet nebulizer connected to an air compressor. Inhale 1 vial (175mcg) once daily (using a mouthpiece).
Children
Not established.
Yupelri Contraindications
Not Applicable
Yupelri Boxed Warnings
Not Applicable
Yupelri Warnings/Precautions
Warnings/Precautions
Do not initiate during acutely deteriorating or potentially life-threatening COPD episodes. Not for treating acute symptoms. Prescribe a short-acting β2-agonist for acute symptoms; monitor for increased need. Do not exceed recommended dose. Discontinue immediately and treat if paradoxical bronchospasm or immediate hypersensitivity reactions occur; use alternative therapy. Narrow-angle glaucoma. Urinary retention. Prostatic hyperplasia. Bladder-neck obstruction. Hepatic impairment: not recommended. Severe renal impairment: monitor. Pregnancy. Nursing mothers.
Yupelri Pharmacokinetics
Absorption
Following inhaled administration, Cmax of revefenacin and its active metabolite occurred at the first postdose sampling time which ranged from 14 to 41 minutes after start of nebulization.
Distribution
Protein binding of revefenacin and its active metabolite in human plasma was on average 71% and 42%, respectively.
Elimination
Terminal half-life of revefenacin and its active metabolite after once-daily is 22 to 70 hours.
Yupelri Interactions
Interactions
Additive effects with concomitant other anticholinergic-containing drugs; avoid. Concomitant OATP1B1 and OATP1B3 inhibitors (eg, rifampicin, cyclosporine): not recommended.
Yupelri Adverse Reactions
Adverse Reactions
Cough, nasopharyngitis, upper respiratory tract infection, headache, back pain; paradoxical bronchospasm.
Yupelri Clinical Trials
Yupelri Note
Not Applicable
Yupelri Patient Counseling
Cost Savings Program
Images
