Xermelo Generic Name & Formulations
Telotristat ethyl 250mg; tabs.
Tryptophan hydroxylase inhibitor.
Tabs—84 (monthly case)
In combination with somatostatin analog (SSA) therapy, to treat carcinoid syndrome diarrhea in adults inadequately controlled by SSA therapy.
Xermelo Dosage and Administration
Take with food. 250mg 3 times daily.
Xermelo Boxed Warnings
Monitor for constipation and/or severe, persistent, or worsening abdominal pain; discontinue if develops. Moderate and severe hepatic impairment: not recommended. ESRD requiring dialysis: not studied. Pregnancy. Nursing mothers: monitor infant for constipation.
May antagonize CYP3A4 (eg, midazolam) or CYP2B6 substrates (eg, bupropion, efavirenz); monitor and consider increasing dose of interacting drug if necessary. Antagonized by short-acting octreotide; if concomitant use is necessary, give dose ≥30mins after Xermelo.
Xermelo Adverse Reactions
Nausea, headache, increased GGT, depression, flatulence, decreased appetite, peripheral edema, pyrexia.
Xermelo Clinical Trials
Xermelo Patient Counseling