• Skin infections (topicals)

Xerese Generic Name & Formulations

General Description

Acyclovir 5% + hydrocortisone 1%; crm.

Pharmacological Class

Antiviral + antiinflammatory.

How Supplied


Xerese Indications


Early treatment of recurrent herpes labialis (cold sores), to reduce likelihood of ulcerative cold sores and shorten lesion healing time in adults and adolescents (≥12yrs old).

Xerese Dosage and Administration


Start as soon as possible after the first signs/symptoms emerge (eg, during the prodrome or when lesions appear). Wash and dry area. Apply topically to affected area on lips or around the mouth 5 times daily for 5 days. Avoid unnecessary rubbing of affected area to avoid aggravating or transferring infection. Do not occlude. Wash hands before and after application; wait ≥30mins before bathing, showering, or swimming.


Not recommended.

Xerese Contraindications

Not Applicable

Xerese Boxed Warnings

Not Applicable

Xerese Warnings/Precautions


Immunocompromised. Reevaluate if symptoms persist more than 2 weeks. Avoid eyes, inside the mouth or nose, or on the genitals. Pregnancy. Nursing mothers.

Xerese Pharmacokinetics

See Literature

Xerese Interactions


Do not apply other products (makeup, sunscreen, lip balm, etc) to area during treatment.

Xerese Adverse Reactions

Adverse Reactions

Drying, flaking, burning/tingling sensation, erythema, pigmentation changes.

Xerese Clinical Trials

See Literature

Xerese Note

Not Applicable

Xerese Patient Counseling

See Literature