• Bacterial infections

Xerava Generic Name & Formulations

General Description

Eravacycline 50mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; preservative-free.

Pharmacological Class

Tetracycline antibiotic.

How Supplied

Single-dose vials—1, 12

Generic Availability


Xerava Indications


Susceptible complicated intra-abdominal infections (cIAI) in patients ≥18yrs of age.

Limitations of Use

Not for the treatment of complicated urinary tract infections (cUTI).

Xerava Dosage and Administration


Calculate dose based on actual body weight. Give by IV infusion over 60mins. ≥18yrs: 1mg/kg every 12hrs for 4–14 days. Severe hepatic impairment (Child Pugh C): 1mg/kg every 12hrs on Day 1, then 1mg/kg every 24hrs starting on Day 2 for a total duration of 4–14 days. Concomitant strong CYP3A inducers: 1.5mg/kg every 12hrs for a total duration of 4–14 days.


<8yrs: not recommended.

Xerava Contraindications

Not Applicable

Xerava Boxed Warnings

Not Applicable

Xerava Warnings/Precautions


Discontinue if allergic reaction or superinfection occurs. Evaluate if diarrhea occurs; discontinue if C. difficile-associated diarrhea is suspected or confirmed. Pregnancy (during 2nd & 3rd trimester): may cause permanent discoloration of the teeth or reversible inhibition of bone growth. Nursing mothers: not recommended (during and for 4 days after the last dose).

Xerava Pharmacokinetics

See Literature

Xerava Interactions


May be antagonized by strong CYP3A inducers; increase dose (see Adults). May need to reduce concomitant anticoagulant dose.

Xerava Adverse Reactions

Adverse Reactions

Infusion site reactions, nausea, vomiting, diarrhea, hypotension, wound dehiscence; hypersensitivity reactions, tooth discoloration, enamel hypoplasia, inhibition of bone growth (up to 8yrs of age), C.difficile-associated diarrhea, photosensitivity, pseudotumor cerebri, increased BUN, azotemia, acidosis, hyperphosphatemia, pancreatitis, abnormal LFTs.

Xerava Clinical Trials

See Literature

Xerava Note

Not Applicable

Xerava Patient Counseling

See Literature