Xeomin

Should be administered and managed by experienced physicians. Max cumulative dose: 400 Units in a treatment session. ≥18yrs: Initial total dose: 20 Units per treatment session divided into 5 equal injections of 4 Units each (2 injections in each corrugator muscle and 1 injection in the procerus muscle). May repeat treatments no sooner than every 12 weeks.

Should be administered and managed by experienced physicians. Use needle electromyographic guidance, nerve stimulation, or ultrasound for localization of the involved muscles. Max cumulative dose: 400 Units in a treatment session. ≥18yrs: Individualize; see full labeling. Chronic sialorrhea: inject 30 Units per side of the parotid gland and 20 Units per side of the submandibular gland (4 total inj sites); total dose: 100 Units per treatment session. Upper limb spasticity (not previously treated): initially give dose at the low end of dosing range and titrate as needed. Cervical dystonia: initial total dose: 120 Units per treatment session. Blepharospasm (treatment-naive): initial total dose: 50 Units (25 Units/eye); (previously-treated): consider dose, response, duration of effect, adverse reactions from previous botulinum toxin A treatment to determine dose. Max 100 Units per treatment session (50 Units/eye). For all: dose, frequency, and number of inj sites should be based on the size, number and location of muscles to be treated, severity, presence of muscle weakness, response to previous treatment, and adverse event history. May repeat treatments no sooner than every 12 weeks (16 weeks for chronic sialorrhea).