• Seizure disorders

Xcopri Generic Name & Formulations

General Description

Cenobamate 12.5mg, 25mg, 50mg, 100mg, 150mg, 200mg; tabs.

Pharmacological Class


How Supplied

Tabs 50mg, 100mg, 150mg, 200mg—30; Blister packs (Titration)—14; (Maintenance)—28


Generic Availability


Xcopri Indications


Partial-onset seizures.

Xcopri Dosage and Administration


Swallow whole. Initially (Weeks 1 & 2): 12.5mg once daily. Titration regimen (Weeks 3 & 4): 25mg once daily; (Weeks 5 & 6): 50mg once daily; (Weeks 7 & 8): 100mg once daily; (Weeks 9 & 10): 150mg once daily. Maintenance (Week 11 & thereafter): 200mg once daily. Maximum dose (if needed based on response and tolerability, may increase by increments of 50mg/day every 2 weeks): 400mg once daily. Mild to moderate hepatic impairment: max 200mg once daily. Withdraw gradually over ≥2 weeks, if discontinuation needed.


Not established.

Xcopri Contraindications


Familial short QT syndrome.

Xcopri Boxed Warnings

Not Applicable

Xcopri Warnings/Precautions


Permanently discontinue if multiorgan hypersensitivity/DRESS occurs. Monitor for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes. Monitor for CNS depression, neurological reactions. Avoid abrupt cessation. Drug abuse. Mild to moderate hepatic impairment: see Adults. Severe hepatic impairment: not recommended. Renal impairment. ESRD on dialysis: not recommended. Elderly. Pregnancy. Advise females of reproductive potential to use additional or alternative non-hormonal contraceptive. Nursing mothers.

Xcopri Pharmacokinetics

See Literature

Xcopri Interactions


May antagonize lamotrigine, carbamazepine, oral contraceptives, CYP2B6 and CYP3A substrates. May potentiate phenytoin (reduce phenytoin dose by up to 50%), phenobarbital, clobazam, CYP2C19 substrates. Caution with other drugs that shorten the QT interval. Increased risk of neurological reactions with other CNS depressants, including alcohol.

Xcopri Adverse Reactions

Adverse Reactions

Somnolence, dizziness, fatigue, diplopia, headache; multiorgan hypersensitivity/DRESS.

Xcopri Clinical Trials

See Literature

Xcopri Note

Not Applicable

Xcopri Patient Counseling

See Literature