• Bacterial infections

Xacduro Generic Name & Formulations

General Description

Sulbactam 1g + durlobactam 0.5g (co-packaged); pwd for IV inj after reconstitution and dilution; preservative-free.

Pharmacological Class

Beta-lactam antibacterial/beta-lactamase inhibitor + beta-lactamase inhibitor.

How Supplied

Kit—1 (sulbactam 1g + durlobactam 2×0.5g single-dose vials)

Generic Availability


Mechanism of Action

Sulbactam is a beta-lactam antibacterial and Ambler Class A serine beta-lactamase inhibitor that has bactericidal activity due to its inhibition of Acinetobacter baumannii-calcoaceticus complex (ABC) penicillin-binding proteins PBP1 and PBP3, which are essential enzymes required for bacterial cell wall synthesis.

Durlobactam is a diazabicyclooctane non-beta-lactam, beta-lactamase inhibitor, that protects sulbactam from degradation by certain serine-beta-lactamases. Durlobactam alone does not have antibacterial activity against ABC isolates.

Xacduro Indications


Hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of Acinetobacter baumanii-calcoaceticus complex. 

Limitations of Use

Not for HABP/VABP caused by pathogens other than susceptible isolates of Acinetobacter baumanii-calcoaceticus complex. 

Xacduro Dosage and Administration


Give by IV infusion over 3hrs. Treatment duration: 7–14 days. Base dose on renal function. ≥18yrs: CrCl ≥130mL/min: 1g/1g every 4hrs; CrCl 45–129mL/min: 1g/1g every 6hrs; CrCl 30–44mL/min: 1g/1g every 8hrs; CrCl 15–29mL/min: 1g/1g every 12hrs; CrCl <15mL/min: 1g/1g every 12hrs for first 3 doses, followed by every 24hrs; those on hemodialysis, give dose after session. 


<18yrs: not established.

Xacduro Contraindications


Other β-lactam antibacterial allergy.

Xacduro Boxed Warnings

Not Applicable

Xacduro Warnings/Precautions


History of beta-lactam hypersensitivity and/or sensitivity to multiple allergens. Discontinue if allergic reactions occur. If C.diff-associated diarrhea (CDAD) suspected or confirmed, assess risk/benefit of continuing treatment. Give appropriate fluid/electrolyte management, protein supplementation, antibacterial treatment, surgical evaluation as indicated. Pregnancy. Nursing mothers. Elderly: monitor renal function.

Xacduro Pharmacokinetics


Plasma protein bound: 38% (sulbactam); 10% (durlobactam).


Renal. Half-life: 2.15 ± 1.16 hours (sulbactam), 2.52 ± 0.77 hours (durlobactam).

Xacduro Interactions


May be potentiated by OAT1 inhibitors (eg, probenecid): avoid concomitant use. 

Xacduro Adverse Reactions

Adverse Reactions

Liver test abnormalities, diarrhea, anemia, hypokalemia; hypersensitivty reactions, C. difficile-associated diarrhea. 

Xacduro Clinical Trials

See Literature

Xacduro Note

Not Applicable

Xacduro Patient Counseling

See Literature