Multiple sclerosis:

Indications for VUMERITY:

Relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.

Adult:

Swallow whole. Initially 231mg twice daily for 7 days, then increase to maintenance dose of 462mg twice daily. If maintenance dose not tolerated, temporarily reduce back to initial dose. Within 4 weeks, resume maintenance dose; if not tolerated, consider discontinuing.

Children:

Not established.

Contraindications:

Concomitant dimethyl fumarate.

Warnings/Precautions:

Obtain a CBC including lymphocyte count prior to initiation, after 6 months, and every 6 to 12 months thereafter; consider interruption if lymphocyte counts <0.5 × 109/L persist for >6 months. Pre-existing low lymphocyte counts: not studied. Serious infection; consider withholding until resolved. Monitor serum aminotransferase, alkaline phosphatase, and total bilirubin prior to initiation and during treatment; discontinue if significant liver injury is suspected. Discontinue if anaphylaxis or angioedema occurs. Withhold and evaluate at first sign/symptom suggestive of PML. Administration with non-enteric coated aspirin (up to 325mg) or food may reduce incidence/severity of flushing. Moderate or severe renal impairment: not recommended. Pregnancy. Nursing mothers.

Interactions:

Avoid concomitant alcohol, high-fat and/or high-calorie meal/snack.

Adverse Reactions:

Flushing, abdominal pain, diarrhea, nausea, vomiting, pruritus, rash, albumin urine present; lymphopenia, liver injury.

Generic Availability:

NO

How Supplied:

Del-rel caps—106 (Starter Pack), 120 (Maintenance Pack)

Pricing for VUMERITY

Maintenance Dose of 231mg bottle (Qty: 1)
Appx. price $7387
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