Vitrakvi Oral Solution Generic Name & Formulations
Vitrakvi Oral Solution Indications
Vitrakvi Oral Solution Dosage and Administration
Adults and Children
Confirm presence of a NTRK gene fusion in tumor specimens. Caps and oral soln are interchangeable. Swallow caps whole. Body surface area (BSA) <1.0m2: 100mg/m2 twice daily; BSA ≥1.0m2: 100mg twice daily. Both: continue until disease progression or unacceptable toxicity. Avoid concomitant strong CYP3A4 inhibitors, if unavoidable, reduce Vitrakvi dose by 50%. Avoid concomitant strong CYP3A4 inducers; if unavoidable, double Vitrakvi dose. Concomitant moderate CYP3A4 inducers: double Vitrakvi dose. Moderate to severe hepatic impairment: reduce initial dose by 50%. Dose modifications for adverse reactions: see full labeling.
Vitrakvi Oral Solution Contraindications
Vitrakvi Oral Solution Boxed Warnings
Vitrakvi Oral Solution Warnings/Precautions
Vitrakvi Oral Solution Pharmacokinetics
Fecal (58%), renal (39%). Half-life: 2.9 hours.
Vitrakvi Oral Solution Interactions
Potentiated by strong CYP3A4 inhibitors (eg, itraconazole, grapefruit, or grapefruit juice); adjust dose (see Adults and Children). Potentiated by moderate CYP3A4 inhibitors; monitor more frequently and reduce dose based on severity of adverse reactions. Antagonized by strong or moderate CYP3A4 inducers (eg, rifampin, St. John's wort); adjust dose (see Adults and Children). Potentiates sensitive CYP3A4 substrates (eg, midazolam); if unavoidable, monitor for adverse reactions.
Vitrakvi Oral Solution Adverse Reactions
Increased AST/ALT, anemia, musculoskeletal pain, fatigue, hypoalbuminemia, neutropenia, increased alkaline phosphatase, cough, leukopenia, constipation, diarrhea, dizziness, hypocalcemia, nausea, vomiting, pyrexia, lymphopenia, abdominal pain.
Vitrakvi Oral Solution Clinical Trials
Vitrakvi Oral Solution Note
Vitrakvi Oral Solution Patient Counseling