• Miscellaneous musculoskeletal disorders

Viltepso Generic Name & Formulations

General Description

Viltolarsen 50mg/mL; soln for IV infusion; preservative-free.

Pharmacological Class

Antisense oligonucleotide.

How Supplied

Single-dose vial (5mL)—1


Generic Availability


Viltepso Indications


Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 53 skipping.

Viltepso Dosage and Administration

Adults and Children

Give as IV infusion over 60mins. 80mg/kg once weekly.

Viltepso Contraindications

Not Applicable

Viltepso Boxed Warnings

Not Applicable

Viltepso Warnings/Precautions


Monitor renal function. Measure baseline serum cystatin C, urine dipstick, urine protein-to-creatinine ratio, and consider measuring GFR prior to initiation. During treatment, monitor urine dipstick monthly, serum cystatin C and urine protein-to-creatinine ratio every 3 months. Refer to pediatric nephrologist if a persistent increase in serum cystatin C or proteinuria is detected. Renal impairment: monitor closely. Pregnancy. Nursing mothers.

Viltepso Pharmacokinetics

See Literature

Viltepso Interactions


Do not mix or infuse with other drugs concomitantly via same IV access line. Avoid pyrogallol red reagent for lab testing; may cause false (+) result for urine protein.

Viltepso Adverse Reactions

Adverse Reactions

Upper RTI, inj site reaction, cough, pyrexia; renal toxicity.

Viltepso Clinical Trials

See Literature

Viltepso Note

Not Applicable

Viltepso Patient Counseling

See Literature