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Viibryd Generic Name & Formulations
Legal Class
Rx
General Description
Vilazodone HCl 10mg, 20mg, 40mg; tabs.
Pharmacological Class
Selective serotonin reuptake inhibitor + 5-HT1A receptor partial agonist.
How Supplied
Tabs—30; Patient Starter Kit (7×10mg tabs + 7×20mg tabs + 16×40mg tabs; 7×10mg tabs + 23×20mg tabs)—30
Manufacturer
Generic Availability
YES
Viibryd Indications
Indications
Major depressive disorder.
Viibryd Dosage and Administration
Adult
Take with food. Initially 10mg once daily for 7 days, then 20mg once daily for 7 days, then increase to 40mg once daily. Concomitant strong CYP3A4 inhibitors: max 20mg once daily. Concomitant strong CYP3A4 inducers for >14 days: consider increasing dose up to 2-fold over 1–2 weeks; max 80mg daily. Readjust to original level when CYP3A4 inhibitors or inducers (in 14 days) are discontinued.
Children
Not established.
Viibryd Contraindications
Contraindications
During or within 14 days of MAOIs; do not start an MAOI during or within 14 days of vilazodone. Concomitant linezolid or IV methylene blue.
Viibryd Boxed Warnings
Boxed Warning
Suicidal thoughts and behaviors.
Viibryd Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening or unusual changes. Screen for bipolar disorder. Monitor for serotonin syndrome; discontinue if occurs. Increased risk of bleeding. History of mania/hypomania. Seizure disorder. Angle-closure glaucoma. Volume depleted. Sexual dysfunction. Avoid abrupt disruption. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Pregnancy: effects on neonates exposed in 3rd trimester (see full labeling). Nursing mothers.
Viibryd Pharmacokinetics
Elimination
Renal. Fecal. Half-life: ~25 hours.
Viibryd Interactions
Interactions
See Contraindications. Avoid alcohol. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Increased risk of bleeding with concomitant aspirin, NSAIDs, warfarin (monitor), other anticoagulants. Potentiated by strong CYP3A4 inhibitors (eg, itraconazole, clarithromycin, voriconazole); see Adult. Antagonized by strong CYP3A4 inducers (eg, carbamazepine, phenytoin, rifampin); see Adult. Monitor digoxin. Caution with other highly protein-bound drugs.
Viibryd Adverse Reactions
Adverse Reactions
Diarrhea, nausea, vomiting, insomnia, headache; hyponatremia/SIADH (esp. in elderly).
Viibryd Clinical Trials
See Literature
Viibryd Note
Not Applicable
Viibryd Patient Counseling
See Literature
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