Indications for VIDEX PEDIATRIC PWD for ORAL SOLN:
HIV-1 infection, in combination with other antiretroviral agents.
Take on an empty stomach. <60kg: 125mg twice daily. ≥60kg: 200mg twice daily. If once daily dosing required: <60kg: 250mg. ≥60kg: 400mg. Renal impairment (CrCl 30–59mL/min): <60kg: 150mg once daily or 75mg twice daily; ≥60kg: 200mg once daily or 100mg twice daily; CrCl 10–29mL/min: <60kg:100mg once daily; ≥60kg: 150mg once daily; CrCl <10mL/min or dialysis: <60kg: 75mg once daily; ≥60kg: 100mg once daily. Concomitant tenofovir DF (CrCl ≥60mL/min): <60kg: 200mg; ≥60kg: 250mg.
Take on an empty stomach. <2wks: not established. 2wks–8mos: 100mg/m2 twice daily. ≥8mos: 120mg/m2 twice daily. Max up to adult dose. Renal impairment: consider reducing dose.
Concomitant stavudine, allopurinol, ribavirin.
Pancreatitis. Lactic acidosis and hepatomegaly with steatosis.
Suspend if signs or symptoms of pancreatitis (discontinue if confirmed), lactic acidosis, or hepatotoxicity (eg, hepatomegaly with steatosis) occurs. Increased risk of pancreatitis (eg, alcohol abuse, advanced HIV disease, elderly, renal impairment); monitor. Women, obesity, or prolonged nucleoside exposure: increased risk of toxicity. Advanced HIV disease, history of neuropathy, or concomitant neurotoxic drugs: consider discontinuing if peripheral neuropathy occurs. Monitor for non-cirrhotic portal hypertension; discontinue if occurs. Monitor for lipoatrophy; use alternative if suspected. Hepatic dysfunction. Do periodic retinal exam. Elderly. Pregnancy. Nursing mothers: not recommended.
Nucleoside analogue (reverse transcriptase inhibitor).
See Contraindications. Avoid with hydroxyurea. Potentiated by ganciclovir, tenofovir DF (see Adults). Antagonized by methadone. Caution with neurotoxic drugs or those that may cause pancreatic toxicity. For pediatric pwd: caution with magnesium- or aluminum-containing antacids. Separate dosing of delavirdine, indinavir, nelfinavir by 1hr; give ketoconazole, itraconazole ≥2hrs prior. May antagonize quinolones, tetracyclines. Give at least 6hrs before or 2hrs after ciprofloxacin.
Diarrhea, peripheral neuropathy, nausea, headache, rash, vomiting; pancreatitis, lactic acidosis, hepatomegaly with steatosis, retinal changes, optic neuritis, immune reconstitution syndrome, non-cirrhotic portal hypertension.
Register pregnant patients exposed to didanosine by calling (800) 258-4263.
Caps—30; pwd—4oz (2g), 8oz (4g)