Vfend Generic Name & Formulations
Vfend Dosage and Administration
Vfend Boxed Warnings
See Contraindications. Potentiates cyclosporine, tacrolimus, phenytoin, warfarin, methadone, fentanyl, alfentanil, oxycodone, other CYP3A4, CYP2C9, or CYP2C19 substrates (eg, benzodiazepines, vinca alkaloids, statins, omeprazole, ivacaftor, other NNRTIs, HIV protease inhibitors, calcium channel blockers, sulfonylureas, NSAIDs); monitor for adverse reactions; adjust dose as needed. Potentiates, and potentiated by oral contraceptives; monitor. Antagonized by phenobarbital, phenytoin, letermovir, possibly delavirdine, efavirenz 300mg every 24hrs, other CYP3A4 inducers. Concomitant everolimus, fluconazole: not recommended. Avoid concomitant low-dose ritonavir (100mg every 12hrs), lemborexant, glasdegib, tyrosine kinase inhibitors; see full labeling. Monitor for adrenal dysfunction with corticosteroids. IV: do not infuse with concomitant blood product or short-term infusion of concentrated electrolytes. Increased risk of skin toxicity with methotrexate.
Vfend Adverse Reactions
Visual disturbances, fever, nausea, vomiting, rash, chills, headache, increased LFTs, tachycardia, hallucinations; infusion-related reactions, cutaneous reactions (eg, SJS, TEN, DRESS), photosensitivity (esp. in children), squamous cell carcinoma (during long-term use), renal toxicity, adrenal dysfunction. Children also: epistaxis, abdominal pain, diarrhea, hypertension, thrombocytopenia, hypokalemia, cough, peripheral edema, ALT abnormal, others.
Vfend Clinical Trials
Vfend Patient Counseling