Vecuronium Bromide For Injection

  • Anesthetics

Vecuronium Bromide For Injection Generic Name & Formulations

General Description

Vecuronium bromide 10mg/10mL; pwd for IV inj after reconstitution; contains benzyl alcohol, mannitol.

Pharmacological Class

Neuromuscular blocker (nondepolarizing).

How Supplied

Contact supplier.

Vecuronium Bromide For Injection Indications


Adjunct to general anesthesia to facilitate endotracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Vecuronium Bromide For Injection Dosage and Administration

Adults and Children

<7wks: not recommended. Individualize. >7wks–10yrs: see literature. ≥10yrs: Relaxation for intubation: inject bolus dose of 0.08–0.1mg/kg; may reduce dose to 0.06–0.085mg/kg if given >5 minutes after start of inhalation agent or when steady state has been achieved. Give 1microgram/kg/min (range: 0.8–1.2microgram/kg/min) by continuous IV infusion 20–40 minutes after initial dose. Inhalation anesthetics (eg, enflurane, isoflurane): reduce infusion rate 25–60%, 45–60 minutes after initial dose. Intubation with succinylcholine: reduce initial vecuronium dose to 0.04–0.06mg/kg with inhalation anesthesia; and to 0.05–0.06mg/kg with balanced anesthesia. Prolonged surgery: maintenance dose of 0.01–0.015mg/kg, within 25–40 minutes of initial dose. During surgery under halothane anesthesia: initial dosing range from 0.15mg/kg up to 0.28mg/kg have been given. Monitor with a peripheral nerve stimulator to avoid overdosage.

Vecuronium Bromide For Injection Contraindications

Not Applicable

Vecuronium Bromide For Injection Boxed Warnings

Not Applicable

Vecuronium Bromide For Injection Warnings/Precautions


To be administered under the supervision of experienced clinicians. Have intubation, artificial respiration, oxygen therapy and reversal agents available. Myasthenia gravis or myasthenic (Eaton-Lambert) syndrome (do test dose and monitor). Renal failure. Hepatic impairment. Cardiovascular disease and edematous state. Long-term use in I.C.U. Immobilized for long periods. Severe obesity or neuromuscular disease; monitor airway and ventilation. Electrolyte imbalance. Adrenal cortical insufficiency. Malignant hyperthermia. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Vecuronium Bromide For Injection Pharmacokinetics

See Literature

Vecuronium Bromide For Injection Interactions


Prior administration of succinylcholine may potentiate effects (delay vecuronium dose). Potentiated by volatile inhalational anesthetics (eg, enflurane, isoflurane, halothane), aminoglycosides, tetracyclines, bacitracin, polymyxin B, colistin, sodium colistimethate, magnesium salts. Additive effects with pancuronium, d-tubocurarine, metocurine, and gallamine. Caution with quinidine injection.

Vecuronium Bromide For Injection Adverse Reactions

Adverse Reactions

Skeletal muscle weakness or prolonged paralysis, muscle atrophy, respiration insufficiency, apnea; rare: hypersensitivity reactions.

Vecuronium Bromide For Injection Clinical Trials

See Literature

Vecuronium Bromide For Injection Note


Formerly known under the brand name Norcuron.

Vecuronium Bromide For Injection Patient Counseling

See Literature