Select therapeutic use:

Arthritis/rheumatic disorders:

Indications for: VAZALORE

Arthritic and rheumatic conditions.

Adult Dosage:

Rheumatoid arthritis, arthritis and pleurisy of SLE: initially 3g daily in divided doses; target plasma salicylate level 150–300mcg/mL. Osteoarthritis: up to 3g/day in divided doses. Spondyloarthropathies: up to 4g/day in divided doses.

Children Dosage:

JRA: initially 90–130mg/kg per day in divided doses; target plasma salicylate level 150–300mcg/mL.

VAZALORE Contraindications:

NSAID allergy. Viral infection in children and teenagers.

VAZALORE Warnings/Precautions:

History of asthma or peptic ulcer. Severe hepatic or renal dysfunction. Hypertension. Cardiovascular disease. Bleeding disorders. Diabetes. Gout. Arthritis. Labor & delivery. Pregnancy (during 3rd trimester), nursing mothers: not recommended.

VAZALORE Classification:

Salicylate.

VAZALORE Interactions:

Potentiates anticoagulants, hypoglycemics, methotrexate, acetazolamide, valproic acid, highly protein-bound drugs. Urinary alkalinizers, antacids, corticosteroids may increase excretion. May antagonize ACE inhibitors, β-blockers, diuretics, uricosurics. Increased bleeding risk with NSAIDs or chronic, heavy alcohol use (≥3 drinks/day). NSAIDs increase risk of renal dysfunction.

Adverse Reactions:

GI upset/bleed, prolonged bleeding time, anaphylaxis, salicylism.

Generic Drug Availability:

NO

How Supplied:

Caps 81mg—12, 30; 325mg—30

Nonnarcotic analgesics:

Recent Updates:

Monograph added.

Indications for: VAZALORE

Pain. Fever.

Adult Dosage:

≥12yrs: 325–650mg every 4hrs or 975mg every 6hrs while symptoms persist; max 3900mg in 24hrs.

Children Dosage:

<12yrs: consult a physician.

VAZALORE Contraindications:

NSAID allergy. Viral infection in children and teenagers.

VAZALORE Warnings/Precautions:

History of asthma or peptic ulcer. Severe hepatic or renal dysfunction. Hypertension. Cardiovascular disease. Bleeding disorders. Diabetes. Gout. Arthritis. Labor & delivery. Pregnancy (during 3rd trimester), nursing mothers: not recommended.

VAZALORE Classification:

Salicylate.

VAZALORE Interactions:

Potentiates anticoagulants, hypoglycemics, methotrexate, acetazolamide, valproic acid, highly protein-bound drugs. Urinary alkalinizers, antacids, corticosteroids may increase excretion. May antagonize ACE inhibitors, β-blockers, diuretics, uricosurics. Increased bleeding risk with NSAIDs or chronic, heavy alcohol use (≥3 drinks/day). NSAIDs increase risk of renal dysfunction.

Adverse Reactions:

GI upset/bleed, prolonged bleeding time, anaphylaxis, salicylism.

Generic Drug Availability:

NO

How Supplied:

Caps 81mg—12, 30; 325mg—30

Thromboembolic disorders:

Indications for: VAZALORE

To reduce combined risk of death and nonfatal stroke after ischemic stroke or TIA. To reduce risk of vascular mortality in suspected acute MI. To reduce combined risk of death and nonfatal MI after MI or unstable angina pectoris. To reduce combined risk of MI and sudden death in chronic stable angina. Revascularization procedures.

Adult Dosage:

Ischemic stroke and TIA: 50–325mg once daily. Suspected acute MI: 160–162.5mg once daily (start as soon as MI suspected) then for at least 30 days post-MI. Prevention of recurrent MI, unstable angina pectoris, chronic stable angina: 75–325mg once daily. Coronary artery bypass graft: 325mg once daily (start 6hrs after procedure) for 1yr. Percutaneous transluminal coronary angioplasty: 325mg 2 hours before surgery, then 160–325mg once daily. Carotid endarterectomy: 80mg once daily to 650mg twice daily (start before surgery).

Children Dosage:

Not recommended.

VAZALORE Contraindications:

NSAID allergy. Viral infection in children and teenagers.

VAZALORE Warnings/Precautions:

History of asthma or peptic ulcer. Severe hepatic or renal dysfunction. Hypertension. Cardiovascular disease. Bleeding disorders. Diabetes. Gout. Arthritis. Labor & delivery. Pregnancy (during 3rd trimester), nursing mothers: not recommended.

VAZALORE Classification:

Antiplatelet.

VAZALORE Interactions:

Potentiates anticoagulants, hypoglycemics, methotrexate, acetazolamide, valproic acid, highly protein-bound drugs. Urinary alkalinizers, antacids, corticosteroids may increase excretion. May antagonize ACE inhibitors, β-blockers, diuretics, uricosurics. Increased bleeding risk with NSAIDs or chronic, heavy alcohol use (≥3 drinks/day). NSAIDs increase risk of renal dysfunction.

Adverse Reactions:

GI upset/bleed, prolonged bleeding time, anaphylaxis, salicylism.

Generic Drug Availability:

NO

How Supplied:

Caps 81mg—12, 30; 325mg—30