Vaccines:

Recent Updates:

Monograph added.

Indications for VAXCHORA:

Immunization against disease caused by Vibrio cholerae serogroup 01 in adults 18–64 years of age traveling to cholera-affected areas.

Limitations of Use:

Efficacy not established in persons living in cholera-affected areas or persons with pre-existing immunity due to previous exposure to V. cholerae or receipt of a cholera vaccine. Not shown to protect against disease caused by V. cholerae serogroup 0139 or other non-01 serogroups.

Adult:

For oral administration only. Avoid food or drink for 60mins before and after administration. ≥18yrs: Give single oral dose a minimum of 10 days before potential cholera exposure.

Children:

<18yrs: not established.</b>

Contraindications:

Severe allergic reaction to any previous cholera vaccine.

Warnings/Precautions:

Immunocompromised. Considering whether to administer to individuals with immunocompromised close contacts. Elderly. Pregnancy.

Pharmacologic Class:

Cholera vaccine.

Interactions:

Avoid use within 14 days of systemic antibiotics. Give vaccine ≥10 days prior to antimalarial prophylaxis with chloroquine. Concomitant immunosuppressive therapy (eg, irradiation, antimetabolites, alkylating agents, cytotoxic drugs, high-dose corticosteroids): may get suboptimal response.

Adverse Reactions:

Tiredness, headache, abdominal pain, nausea/vomiting, lack of appetite, diarrhea.

Note:

To enroll patients in the pregnancy exposure registry call (800) 533-5899.

Generic Availability:

NO

How Supplied:

Single-dose carton—2 packets (buffer component + active component)