• Hyperlipoproteinemias

Vascepa Generic Name & Formulations

General Description

Icosapent ethyl 0.5g, 1g; soft gelatin caps.

Pharmacological Class

Lipid-regulating agent.

How Supplied

Caps 0.5g—240; 1g—120


Generic Availability


Vascepa Indications


Adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable angina requiring hospitalization in adults with elevated triglyceride (TG) levels (≥150mg/dL) and established cardiovascular disease (CVD), or diabetes plus ≥2 additional CVD risk factors. Adjunct to diet to reduce TG levels in adults with severe hypertriglyceridemia (≥500mg/dL).

Limitations of Use

The effect of Vascepa on the risk for pancreatitis in patients with severe hypertriglyceridemia has not been determined.

Vascepa Dosage and Administration


Swallow whole. 4 caps (0.5g) or 2 caps (1g) twice daily with food; max 4g/day.


Not established.

Vascepa Contraindications

Not Applicable

Vascepa Boxed Warnings

Not Applicable

Vascepa Warnings/Precautions


Obtain baseline lipids before initiating therapy. Identify other causes of high triglycerides and manage appropriately (eg, diabetes, hypothyroidism, or alcohol intake). Increased risk of atrial fibrillation or atrial flutter requiring hospitalization. Bleeding events. Hepatic impairment; monitor ALT/AST levels periodically during therapy. Fish and/or shellfish allergy. Pregnancy. Nursing mothers.

Vascepa Pharmacokinetics

See Literature

Vascepa Interactions


Increased risk of bleeding with concomitant antithrombotics (eg, aspirin, clopidogrel, warfarin); monitor.

Vascepa Adverse Reactions

Adverse Reactions

Musculoskeletal pain, peripheral edema, constipation, gout, atrial fibrillation, arthralgia, oropharyngeal pain.

Vascepa Clinical Trials

See Literature

Vascepa Note

Not Applicable

Vascepa Patient Counseling

See Literature