Valtrex Generic Name & Formulations
Valacyclovir (as HCl) (prodrug of acyclovir) 500mg, 1g+; tabs; +scored.
Treatment of herpes labialis or herpes zoster. Treatment of initial or recurrent episodes of genital herpes in immunocompetent adults. Chronic suppression of recurrent genital herpes in immunocompetent and HIV-infected adults. Reduction of transmission of genital herpes in immunocompetent heterosexual adults. Treatment of chickenpox in immunocompetent children.
Valtrex Dosage and Administration
Begin at onset of signs/symptoms (within 48hrs for herpes zoster or initial episode of genital herpes). Coincide a dose for after hemodialysis. ≥12yrs: Herpes labialis (treat for max 1 day): 2g every 12hrs; CrCl 30–49mL/min: 1g every 12hrs; CrCl 10–29mL/min: 500mg every 12hrs; CrCl <10mL/min: 500mg once. ≥18yrs: Herpes zoster: 1g every 8hrs; CrCl 30–49mL/min: 1g every 12hrs; CrCl 10–29mL/min: 1g every 24hrs; CrCl <10mL/min: 500mg every 24hrs; all for 7 days. Initial episode of genital herpes: 1g every 12hrs; CrCl 10–29mL/min: 1g every 24hrs; CrCl <10mL/min: 500mg every 24hrs; all for 10 days. Treatment of recurrent genital herpes: 500mg every 12hrs; CrCl ≤29mL/min: 500mg every 24hrs; both for 3 days. Suppression of recurrent genital herpes: in immunocompetent (>9 episodes/yr): 1g every 24hrs; CrCl ≤29mL/min: 500mg every 24hrs; (≤9 episodes/yr): 500mg every 24hrs; CrCl ≤29mL/min: 500mg every 48hrs; in HIV-infected: 500mg every 12hrs; CrCl ≤29mL/min: 500mg every 24hrs. Reduction of genital herpes transmission (≤9 episodes/yr): 500mg every 24hrs for source partner (and use safer sex practices).
Herpes labialis: <12yrs: not established. Herpes zoster or genital herpes <18yrs: not established. Chickenpox: <2yrs or ≥18yrs: not established. Begin at onset of signs/symptoms. 2–<18yrs: 20mg/kg three times daily for 5 days; max 1g three times daily. CrCl<50mL/min: no data.
Valtrex Boxed Warnings
Risk of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in advanced HIV-1 disease or transplant recipients on 8g/day; discontinue immediately if occurs. Underlying renal disease. Maintain adequate hydration. Elderly. Pregnancy. Nursing mothers.
Caution with nephrotoxic drugs.
Valtrex Adverse Reactions
Headache, nausea, abdominal pain; acute renal failure, CNS effects (esp. elderly; discontinue if occur).
Valtrex Clinical Trials
Valtrex Patient Counseling