• Leukemias, lymphomas, and other hematologic cancers

Valchlor Generic Name & Formulations

General Description

Mechlorethamine 0.016%; topical gel; contains propylene glycol, isopropyl alcohol.

Pharmacological Class

Alkylating agent.

How Supplied


Valchlor Indications


Treatment of Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma in patients who have received prior skin-directed therapy.

Valchlor Dosage and Administration


Apply a thin film once daily to affected areas of the skin. Apply to completely dry skin ≥4 hours before or 30 minutes after showering or washing. Allow treated areas to completely dry for 5–10 minutes after applying. Wash hands thoroughly after application. Discontinue if any grade of skin ulceration, blistering, or moderately-to-severe, or severe dermatitis occur; restart at reduced frequency of once every 3 days upon improvement; if reintroduction is tolerated for at least 1 week, can increase to every other day for 1 week and then once daily if tolerated.


Not established.

Valchlor Contraindications

Not Applicable

Valchlor Boxed Warnings

Not Applicable

Valchlor Warnings/Precautions


Mucosal (oral, nasal) or eye exposure; blindness and severe irreversible anterior eye injury may occur; immediately irrigate for ≥15 minutes with copious amounts of water. Secondary exposure; avoid direct skin contact with patient. Risk of dermatitis (eg, face, genitalia, anus, and intertriginous skin); monitor for redness, swelling, inflammation, itchiness, blisters, ulceration, and secondary skin infections. Monitor for nonmelanoma skin cancer during and after treatment. Flammable (avoid fire, flame until gel has dried). Embryo-fetal toxicity. Advise females and males of reproductive potential to use effective contraception during therapy (including a barrier method to avoid direct exposure). Pregnancy. Nursing mothers: not recommended.

Valchlor Pharmacokinetics

See Literature

Valchlor Interactions

Not Applicable

Valchlor Adverse Reactions

Adverse Reactions

Dermatitis, pruritus, bacterial skin infection, skin ulceration or blistering, hyperpigmentation.

Valchlor Clinical Trials

See Literature

Valchlor Note

Not Applicable

Valchlor Patient Counseling

See Literature