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Vabomere Generic Name & Formulations
Legal Class
Rx
General Description
Meropenem, vaborbactam 2g/vial (containing meropenem 1g + vaborbactam 1g); pwd for IV infusion after reconstitution and dilution; sodium content 10.9mEq/vial; preservative-free.
Pharmacological Class
Carbapenem + beta-lactamase inhibitor.
How Supplied
Single-dose vials—6
Manufacturer
Generic Availability
NO
Vabomere Indications
Indications
Susceptible complicated urinary tract infections (cUTI) including pyelonephritis.
Vabomere Dosage and Administration
Adult
Give by IV infusion over 3hrs. ≥18yrs (eGFR ≥50mL/min/1.73m2): 4g every 8hrs. Renal impairment (eGFR 30–49mL/min/1.73m2): 2g every 8hrs; (eGFR 15–29mL/min/1.73m2): 2g every 12hrs; (eGFR <15mL/min/1.73m2): 1g every 12hrs. Give after hemodialysis session. All: treat for up to 14 days.
Children
<18yrs: not established.
Vabomere Contraindications
Not Applicable
Vabomere Boxed Warnings
Not Applicable
Vabomere Warnings/Precautions
Warnings/Precautions
Previous hypersensitivity to penicillins, cephalosporins, other beta-lactams, or other allergens. Discontinue immediately if allergic reaction occurs. CNS disorders (eg, brain lesions, history of seizures). Bacterial meningitis. Renal impairment (thrombocytopenia possible). Reevaluate dose if focal tremors, myoclonus, or seizures occur. Discontinue if C. difficile-associated diarrhea suspected or confirmed. Pregnancy. Nursing mothers.
Vabomere Pharmacokinetics
See Literature
Vabomere Interactions
Interactions
Concomitant valproic acid or divalproex sodium: not recommended; if use necessary, consider supplemental anticonvulsant. Potentiated by probenecid: not recommended.
Vabomere Adverse Reactions
Adverse Reactions
Headache, phlebitis/infusion site reactions, diarrhea; serious hypersensitivity reactions, C. difficile-associated diarrhea, possible neuromotor impairment (eg, seizures, delirium, paresthesias), superinfection.
Vabomere Clinical Trials
See Literature
Vabomere Note
Not Applicable
Vabomere Patient Counseling
See Literature
