• Urine acidification/alkalinization

Urocit-k Generic Name & Formulations

General Description

Potassium citrate 5mEq (540mg), 10mEq (1080mg), 15mEq (1620mg); tabs.

Pharmacological Class

Urinary alkalinizer.

How Supplied


Generic Availability


Urocit-k Indications


Renal tubular acidosis with calcium stones. Hypocitraturic calcium oxalate nephrolithiasis. Uric acid lithiasis.

Urocit-k Dosage and Administration


Take within 30mins of meals or bedtime snack. Adjust based on urinary citrate levels and/or pH. Urinary citrate <150mg/day: 30mEq twice daily or 20mEq 3 times daily. Urinary citrate >150mEq/day: 15mEq twice daily or 10mEq 3 times daily. Max 100mEq/day.


Not established.

Urocit-k Contraindications


See full labeling. Hyperkalemia or predisposing conditions. Delayed gastric emptying, esophageal compression, intestinal obstruction or stricture. Peptic ulcer disease. UTI. Renal insufficiency (GFR <0.7mL/kg/min).

Urocit-k Boxed Warnings

Not Applicable

Urocit-k Warnings/Precautions


Restrict salt intake and encourage high fluid intake. Discontinue if severe vomiting, GI pain or bleeding occurs and follow-up. Monitor 24 hour urinary citrate, urinary pH, serum electrolytes, CBC, ECG, at least every 4 months; discontinue if hyperkalemia, significant rise in serum creatinine, or significant fall in hematocrit or hemoglobin occurs. Pregnancy. Nursing mothers.

Urocit-k Pharmacokinetics

See Literature

Urocit-k Interactions


Avoid concomitant potassium-sparing diuretics, anticholinergics, other drugs that slow GI motility. Monitor digoxin. May interfere with some urinary tract antibiotics. Concomitant NSAIDs, RAAS inhibitors (eg, ACEIs, ARBs, spironolactone, eplerenone, aliskiren): closely monitor potassium levels.

Urocit-k Adverse Reactions

Adverse Reactions

Hyperkalemia, GI upset, irritation, bleeding.

Urocit-k Clinical Trials

See Literature

Urocit-k Note

Not Applicable

Urocit-k Patient Counseling

See Literature