• Pulmonary hypertension

Uptravi Generic Name & Formulations

General Description

Selexipag 200mcg, 400mcg, 600mcg, 800mcg, 1000mcg, 1200mcg, 1400mcg, 1600mcg; tabs.

Pharmacological Class

Prostacyclin receptor agonist.

How Supplied

Tabs 200mcg—60, 140; 400mcg, 600mcg, 800mcg, 1000mcg, 1200mcg, 1400mcg, 1600mcg—60; Titration pack—1 (140 x 200mcg tabs) + (60 x 800mcg tabs); Single-dose vial (10mL)—1

Generic Availability


Uptravi Indications


Pulmonary arterial hypertension (PAH) (WHO Group 1) in patients with WHO functional Class II–III symptoms, to delay disease progression and reduce the risk of hospitalization for PAH.

Uptravi Dosage and Administration


Swallow whole; may take with food to improve tolerability. Initially 200mcg twice daily; increase by 200mcg increments twice daily at weekly intervals to highest tolerated dose up to 1600mcg twice daily; reduce to previous dose if not tolerated. Moderate hepatic impairment (Child-Pugh class B): initially 200mcg once daily; increase in 200mcg increments once daily at weekly intervals as tolerated. Concomitant moderate CYP2C8 inhibitors: reduce Uptravi dose to once daily.


Not established.

Uptravi Contraindications


Concomitant strong CYP2C8 inhibitors (eg, gemfibrozil).

Uptravi Boxed Warnings

Not Applicable

Uptravi Warnings/Precautions


Discontinue if pulmonary veno-occlusive disease confirmed. Severe hepatic impairment (Child-Pugh class C): avoid. Pregnancy. Nursing mothers: not recommended.

Uptravi Pharmacokinetics

See Literature

Uptravi Interactions


See Contraindications. Potentiated by moderate CYP2C8 inhibitors (eg, clopidogrel, deferasirox, teriflunomide); reduce dosing (see Adults). Antagonized by CYP2C8 and UGT 1A3 or 2B7 inducers (eg, rifampin); increase up to twice the dose.

Uptravi Adverse Reactions

Adverse Reactions

Headache, diarrhea, nausea, jaw pain, vomiting, pain in extremity, myalgia, flushing, arthralgia, rash, anemia, decreased appetite.

Uptravi Clinical Trials

See Literature

Uptravi Note

Not Applicable

Uptravi Patient Counseling

See Literature