Unasyn

— THERAPEUTIC DISORDERS TREATED —
  • Bacterial infections

Unasyn Generic Name & Formulations

General Description

Ampicillin sodium 1g, sulbactam sodium 0.5g (1.5g vial); or ampicillin sodium 2g, sulbactam sodium 1g (3g vial); IM or IV inj; sodium content 5mEq/g of ampicillin.

Pharmacological Class

Broad-spectrum penicillin + β-lactamase inhibitor.

How Supplied

Vials (1.5g, 3g)—1

Manufacturer

Generic Availability

YES

Unasyn Indications

Indications

Susceptible skin and skin structure, intraabdominal, gynecologic infections.

Unasyn Dosage and Administration

Adult

Dose is given as ampicillin + sulbactam. Normal renal function (CrCl ≥30mL/min): 1.5–3g IM or IV every 6hrs; CrCl 15–29mL/min: 1.5–3g every 12hrs; CrCl 5–14mL/min: 1.5–3g every 24hrs.

Children

Intraabdominal infections: not established. Dose is given as ampicillin + sulbactam. <1yr: not established. ≥1yr (<40kg): 300mg/kg per day IV in equally divided doses every 6hrs; usual max 14 days. ≥40kg: as adult.

Unasyn Contraindications

Contraindications

History of cholestatic jaundice/hepatic dysfunction due to Unasyn. Penicillin, cephalosporin, or other β-lactam allergy.

Unasyn Boxed Warnings

Not Applicable

Unasyn Warnings/Precautions

Warnings/Precautions

Mononucleosis: not recommended. Discontinue if superinfection or hypersensitivity reactions occur, or if skin lesions progress. Hepatic impairment; monitor LFTs regularly. Pregnancy. Nursing mothers.

Unasyn Pharmacokinetics

See Literature

Unasyn Interactions

Interactions

Potentiated by probenecid. Increased incidence of rash with allopurinol. May cause false (+) Clinitest, Benedict's or Fehling's soln.

Unasyn Adverse Reactions

Adverse Reactions

Inj site reactions, diarrhea, rash, blood dyscrasias; C. difficile-associated diarrhea (evaluate if occurs), hypersensitivity or severe skin reactions (eg, SJS, TEN, dermatitis exfoliative, erythema multiforme, AGEP), hepatotoxicity.

Unasyn Clinical Trials

See Literature

Unasyn Note

Not Applicable

Unasyn Patient Counseling

See Literature