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Unasyn Generic Name & Formulations
Legal Class
Rx
General Description
Ampicillin sodium 1g, sulbactam sodium 0.5g (1.5g vial); or ampicillin sodium 2g, sulbactam sodium 1g (3g vial); IM or IV inj; sodium content 5mEq/g of ampicillin.
Pharmacological Class
Broad-spectrum penicillin + β-lactamase inhibitor.
How Supplied
Vials (1.5g, 3g)—1
Manufacturer
Generic Availability
YES
Unasyn Indications
Indications
Susceptible skin and skin structure, intraabdominal, gynecologic infections.
Unasyn Dosage and Administration
Adult
Dose is given as ampicillin + sulbactam. Normal renal function (CrCl ≥30mL/min): 1.5–3g IM or IV every 6hrs; CrCl 15–29mL/min: 1.5–3g every 12hrs; CrCl 5–14mL/min: 1.5–3g every 24hrs.
Children
Intraabdominal infections: not established. Dose is given as ampicillin + sulbactam. <1yr: not established. ≥1yr (<40kg): 300mg/kg per day IV in equally divided doses every 6hrs; usual max 14 days. ≥40kg: as adult.
Unasyn Contraindications
Contraindications
History of cholestatic jaundice/hepatic dysfunction due to Unasyn. Penicillin, cephalosporin, or other β-lactam allergy.
Unasyn Boxed Warnings
Not Applicable
Unasyn Warnings/Precautions
Warnings/Precautions
Mononucleosis: not recommended. Discontinue if superinfection or hypersensitivity reactions occur, or if skin lesions progress. Hepatic impairment; monitor LFTs regularly. Pregnancy. Nursing mothers.
Unasyn Pharmacokinetics
See Literature
Unasyn Interactions
Interactions
Potentiated by probenecid. Increased incidence of rash with allopurinol. May cause false (+) Clinitest, Benedict's or Fehling's soln.
Unasyn Adverse Reactions
Adverse Reactions
Inj site reactions, diarrhea, rash, blood dyscrasias; C. difficile-associated diarrhea (evaluate if occurs), hypersensitivity or severe skin reactions (eg, SJS, TEN, dermatitis exfoliative, erythema multiforme, AGEP), hepatotoxicity.
Unasyn Clinical Trials
See Literature
Unasyn Note
Not Applicable
Unasyn Patient Counseling
See Literature
