• Anesthetics

Ultane Generic Name & Formulations

General Description

Sevoflurane; volatile liq for inhalation.

Pharmacological Class

Inhalation anesthetic.

How Supplied

Bottle (250mL)—1


Generic Availability


Ultane Indications


Induction and maintenance of general anesthesia for surgery.

Ultane Dosage and Administration

Adults and Children

Use sevoflurane calibrated vaporizer. Individualize. Surgical maintenance: usually 0.5–3% sevoflurane with or without nitrous oxide. May be administered with any type of anesthesia circuit. See full labeling for minimum alveolar concentration (MAC) values based on age.

Ultane Contraindications


Genetic susceptibility to malignant hyperthermia. Sensitivity to halogenated agents.

Ultane Boxed Warnings

Not Applicable

Ultane Warnings/Precautions


To be administered only by those experienced in general anesthesia. Have intubation, artificial ventilation, oxygen and circulatory resuscitation available. Sevoflurane exposure >2 MAC hours at flow rates 1 to <2L/min and fresh gas flow rates <1L/min: not recommended. Renal insufficiency. Severe hepatic impairment. Monitor BP, HR, ECG, hepatic and renal function, respiration, urine flow during treatment. Susceptible to congenital long QT syndrome. Risk of malignant hyperthermia; discontinue all triggering agents if suspected (eg, volatile anesthetic agents, succinylcholine). Neuromuscular disease (eg, Duchenne muscular dystrophy). Desiccated CO2 absorbents. Pediatric neurotoxicity risk with repeated or prolonged use. Bradycardia in pediatrics with Down syndrome. Elderly. Premature infants. Labor & delivery. Pregnancy. Nursing mothers.

Ultane Pharmacokinetics


Hepatic (CYP2E1).


Renal (minor).

Ultane Interactions


Concomitant KOH containing CO2 absorbents: not recommended. Risk of ventricular arrhythmias with epinephrine. Hyperkalemia with succinylcholine. Marked hypotension with calcium antagonists. Increased risk of hemodynamic instability during surgical/medical procedures with MAO inhibitors. Potentiated by benzodiazepines, opioids, nitrous oxide. Potentiates neuromuscular blockers (eg, pancuronium, vecuronium, atracurium). Caution with concomitant drugs that prolong the QT interval.

Ultane Adverse Reactions

Adverse Reactions

Nausea, vomiting, agitation, somnolence, dizziness, increased salivation, tachycardia, bradycardia, hypotension, cough increased, laryngospasm, airway obstruction, breath holding, shivering, apnea, hypertension; perioperative hyperkalemia, renal injury (eg, glycosuria and proteinuria); rare: seizures (esp. children), post-op hepatic dysfunction, hepatitis, torsades de pointes, transient elevations in glucose, LFTs, WBC count.

Ultane Clinical Trials

See Literature

Ultane Note

Not Applicable

Ultane Patient Counseling

See Literature