Migraine and headache:

Indications for UBRELVY:

Acute treatment of migraine with or without aura.

Limitations of Use:

Not for preventive treatment of migraine.

Adult:

Initially 50mg or 100mg; may give a second dose at least 2hrs after initial dose (max 200mg/day). Concomitant use with moderate CYP3A4 inhibitors: initially 50mg, avoid second dose within 24hrs. Concomitant use with BCRP and/or P-gp only inhibitors or weak CYP3A4 inhibitors: initially 50mg; may give second dose after 2hrs (if needed). Concomitant use with moderate or weak CYP3A4 inducers: initially 100mg; may give second dose after 2hrs (if needed). Severe hepatic (Child-Pugh Class C) or renal (CrCl 15–29mL/min) impairment: initially 50mg; may give second dose after 2hrs (if needed). The safety of treating more than 8 migraines in a 30-day period has not been established.

Children:

Not established.

Contraindications:

Concomitant use with strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin).

Warnings/Precautions:

Severe hepatic (Child-Pugh Class C) or severe renal (CrCl 15–29mL/min) impairment: See Adults. ESRD (CrCl <15mL/min): avoid. Elderly. Pregnancy. Nursing mothers.

Pharmacologic Class:

Calcitonin gene-related peptide (CGRP) receptor antagonist.

Interactions:

See Contraindications. Potentiated by moderate CYP3A4 inhibitors (eg, cyclosporine, ciprofloxacin, fluconazole, fluvoxamine, grapefruit juice); adjust doses (see Adults). May be potentiated by BCRP and/or P-gp only inhibitors (eg, quinidine, carvedilol, eltrombopag, curcumin); adjust doses. Antagonized by strong CYP3A4 inducers (eg, phenytoin, barbiturates, rifampin, St. John's wort); avoid. Concomitant moderate or weak CYP3A4 inducers: adjust doses (see Adults).

Adverse Reactions:

Nausea, somnolence.

Generic Availability:

NO

How Supplied:

Packets—6, 8, 10, 12, 30

Pricing for UBRELVY

50mg tablet (Qty: 10)
Appx. price $877
GoodRx