• Bacterial infections

Tygacil Generic Name & Formulations

General Description

Tigecycline 50mg/vial; lyophilized pwd for IV infusion after reconstitution and dilution; preservative-free.

Pharmacological Class

Tetracycline antibiotic.

How Supplied

Single-use vials (5mL, 10mL)—10


Generic Availability


Tygacil Indications


Susceptible complicated skin and skin structure and intra-abdominal infections. Community-acquired bacterial pneumonia (CABP).

Limitations of Use

Not for treating diabetic foot infection, hospital-acquired or ventilator-associated pneumonia.

Tygacil Dosage and Administration


≥18yrs: Give by IV infusion over 30–60 mins. 100mg once, then 50mg every 12hrs. Skin, skin structure, and intra-abdominal infections: treat for 5–14 days. CABP: treat for 7–14 days. Severe hepatic impairment (Child Pugh C): 100mg once, then 25mg every 12hrs.


<18yrs: not recommended. See full labeling for suggested dosages when no alternative antibacterial drugs are available.

Tygacil Contraindications

Not Applicable

Tygacil Boxed Warnings

Boxed Warning

All-cause mortality.

Tygacil Warnings/Precautions


Risk of increase in all-cause mortality; reserve for use when alternatives are not suitable. Monitor for hepatic dysfunction and pancreatitis; consider discontinuing if occurs. Ventilator-associated pneumonia. Complicated intra-abdominal infections secondary to intestinal perforation: avoid monotherapy (sepsis/septic shock may develop). Monitor blood coagulation parameters (including fibrinogen) at baseline and during treatment. Severe hepatic impairment. Risk of tooth discoloration, enamel hypoplasia, and reversible bone growth inhibition (during 2nd/3rd trimester of pregnancy, infancy, and childhood up to age 8yrs). Pregnancy (2nd/3rd trimester). Nursing mothers (avoid if therapy >3 weeks): may consider interrupting breastfeeding and pumping and discarding breastmilk during and for 9 days after the last dose.

Tygacil Pharmacokinetics

See Literature

Tygacil Interactions


Monitor warfarin. May potentiate calcineurin inhibitors (eg, cyclosporine, tacrolimus); monitor. May antagonize oral contraceptives.

Tygacil Adverse Reactions

Adverse Reactions

Nausea, vomiting, diarrhea, abdominal pain, headache, increased SGPT; pancreatitis, anaphylaxis, hypofibrinogenemia, C. difficile-associated diarrhea.

Tygacil Clinical Trials

See Literature

Tygacil Note

Not Applicable

Tygacil Patient Counseling

See Literature