Tussionex Pennkinetic

  • Cough and cold

Tussionex Pennkinetic Generic Name & Formulations

General Description

Hydrocodone bitartrate 10mg, chlorpheniramine maleate 8mg; per 5mL; as polistirex; ext-rel susp.

Pharmacological Class

Antitussive + antihistamine.

How Supplied



Tussionex Pennkinetic Indications


Cough and upper respiratory symptoms associated with allergy or cold.

Tussionex Pennkinetic Dosage and Administration


Use accurate measuring device. ≥12yrs: 5mL every 12hrs; max 10mL/24hrs.


Use accurate measuring device. <6yrs: see Contraindications. 6–11yrs: 2.5mL every 12hrs; max 5mL/24hrs.

Tussionex Pennkinetic Contraindications


Children <6yrs of age.

Tussionex Pennkinetic Boxed Warnings

Not Applicable

Tussionex Pennkinetic Warnings/Precautions


Risks from concomitant benzodiazepines or other CNS depressants (see Interactions). Respiratory depression esp. in children; discontinue if occurs. Post-op. Compromised respiratory function (eg, pulmonary disease). Abuse potential (monitor). Head injury, other intracranial lesions or pre-existing increase in intracranial pressure. Acute abdomen. Underlying intestinal motility disorders. Narrow-angle glaucoma. Asthma. Hypothyroidism. Addison’s disease. Prostatic hypertrophy. Urethral stricture. Severe hepatic or renal impairment. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Tussionex Pennkinetic Pharmacokinetics

See Literature

Tussionex Pennkinetic Interactions


Increased risk of respiratory depression, sedation with benzodiazepines or other CNS depressants (eg, opioids, antihistamines, antipsychotics, anxiolytics, alcohol); avoid. May affect or be affected by MAOIs, TCAs. Paralytic ileus may occur with anticholinergics.

Tussionex Pennkinetic Adverse Reactions

Adverse Reactions

Nausea, vomiting, sedation, drowsiness, impairment of mental and physical performance, dysphoria, rash, pruritus; respiratory depression.

Tussionex Pennkinetic Clinical Trials

See Literature

Tussionex Pennkinetic Note

Not Applicable

Tussionex Pennkinetic Patient Counseling

See Literature