Trulance

— THERAPEUTIC DISORDERS TREATED —
  • Colorectal disorders
  • Constipation and bowel cleansers

Trulance Generic Name & Formulations

General Description

Plecanatide 3mg; tabs.

Pharmacological Class

Guanylate cyclase-C agonist.

How Supplied

Tabs—30

Generic Availability

NO

Trulance Indications

Indications

Irritable bowel syndrome with constipation (IBS-C).

Trulance Dosage and Administration

Adult

Take with or without food. Swallow whole; if difficulties in swallowing, may crush tabs and mix in applesauce or water; may also give with water via NG or gastric feeding tube. ≥18yrs: 3mg once daily.

Children

<6yrs: contraindicated. 6–<18yrs: avoid.

Trulance Contraindications

Contraindications

Children <6yrs old. Known or suspected mechanical GI obstruction.

Trulance Boxed Warnings

Boxed Warning

Risk of serious dehydration in pediatric patients.

Trulance Warnings/Precautions

Warnings/Precautions

Avoid use in patients 6–<18yrs of age. Suspend dosing and rehydrate if severe diarrhea occurs. Pregnancy. Nursing mothers.

Trulance Pharmacokinetics

See Literature

Trulance Interactions

Trulance Adverse Reactions

Adverse Reactions

Diarrhea (may be severe), sinusitis, URTI, abdominal distension/tenderness, flatulence, increased liver enzymes, nausea, nasopharyngitis, UTI, dizziness.

Trulance Clinical Trials

See Literature

Trulance Note

Not Applicable

Trulance Patient Counseling

See Literature

Trulance Generic Name & Formulations

General Description

Plecanatide 3mg; tabs.

Pharmacological Class

Guanylate cyclase-C agonist.

How Supplied

Tabs—30

Generic Availability

NO

Trulance Indications

Indications

Chronic idiopathic constipation (CIC).

Trulance Dosage and Administration

Adult

Take with or without food. Swallow whole; if difficulties in swallowing, may crush tabs and mix in applesauce or water; may also give with water via NG or gastric feeding tube. ≥18yrs: 3mg once daily.

Children

<6yrs: contraindicated. 6–<18yrs: avoid.

Trulance Contraindications

Contraindications

Children <6yrs old. Known or suspected mechanical GI obstruction.

Trulance Boxed Warnings

Boxed Warning

Risk of serious dehydration in pediatric patients.

Trulance Warnings/Precautions

Warnings/Precautions

Avoid use in patients 6–<18yrs of age. Suspend dosing and rehydrate if severe diarrhea occurs. Pregnancy. Nursing mothers.

Trulance Pharmacokinetics

See Literature

Trulance Interactions

Trulance Adverse Reactions

Adverse Reactions

Diarrhea (may be severe), sinusitis, URTI, abdominal distension/tenderness, flatulence, increased liver enzymes, nausea, nasopharyngitis, UTI, dizziness.

Trulance Clinical Trials

See Literature

Trulance Note

Not Applicable

Trulance Patient Counseling

See Literature

Images