Trospium Chloride

  • Overactive bladder/enuresis

Trospium Chloride Generic Name & Formulations

General Description

Trospium chloride 20mg; tabs.

Pharmacological Class

Muscarinic antagonist.

How Supplied

Contact supplier

Trospium Chloride Indications


Overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

Trospium Chloride Dosage and Administration


Take on empty stomach. 20mg twice daily. ≥75yrs: 20mg once daily if twice daily dose not tolerated. Severe renal impairment (CrCl<30mL/min): 20mg once daily at bedtime.


Not established.

Trospium Chloride Contraindications


Gastric or urinary retention; uncontrolled narrow-angle glaucoma; and patients at risk for these conditions.

Trospium Chloride Boxed Warnings

Not Applicable

Trospium Chloride Warnings/Precautions


Bladder outflow obstruction. GI obstructive disorders. Ulcerative colitis. Narrow-angle glaucoma (monitor). Intestinal atony. Myasthenia gravis. Exposure to high environmental temperature. Renal insufficiency (CrCl 30–80mL/min). Moderate to severe hepatic dysfunction. Pregnancy (Cat.C). Nursing mothers.

Trospium Chloride Pharmacokinetics

See Literature

Trospium Chloride Interactions


Additive anticholinergic effects with other anticholinergics. Increased drowsiness with alcohol; avoid consumption within 2hrs of administration. May alter absorption of other drugs (decreased GI motility). May potentiate or be potentiated by drugs eliminated by active tubular secretion. May be antagonized by metformin.

Trospium Chloride Adverse Reactions

Adverse Reactions

Anticholinergic effects (dry mouth, constipation, dry eyes, urinary retention, blurred vision), CNS effects (monitor), dyspepsia, headache.

Trospium Chloride Clinical Trials

See Literature

Trospium Chloride Note


Formerly known under the brand name Sanctura, Sanctura XR.

Trospium Chloride Patient Counseling

See Literature