Overactive bladder/enuresis:

Indications for Trospium Chloride:

Overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

Adult Dosage:

Take on empty stomach. 20mg twice daily. ≥75yrs: 20mg once daily if twice daily dose not tolerated. Severe renal impairment (CrCl<30mL/min): 20mg once daily at bedtime.

Children Dosage:

Not established.

Trospium Chloride Contraindications:

Gastric or urinary retention; uncontrolled narrow-angle glaucoma; and patients at risk for these conditions.

Trospium Chloride Warnings/Precautions:

Bladder outflow obstruction. GI obstructive disorders. Ulcerative colitis. Narrow-angle glaucoma (monitor). Intestinal atony. Myasthenia gravis. Exposure to high environmental temperature. Renal insufficiency (CrCl 30–80mL/min). Moderate to severe hepatic dysfunction. Pregnancy (Cat.C). Nursing mothers.

Trospium Chloride Classification:

Muscarinic antagonist.

Trospium Chloride Interactions:

Additive anticholinergic effects with other anticholinergics. Increased drowsiness with alcohol; avoid consumption within 2hrs of administration. May alter absorption of other drugs (decreased GI motility). May potentiate or be potentiated by drugs eliminated by active tubular secretion. May be antagonized by metformin.

Adverse Reactions:

Anticholinergic effects (dry mouth, constipation, dry eyes, urinary retention, blurred vision), CNS effects (monitor), dyspepsia, headache.

Note:

Formerly known under the brand name Sanctura, Sanctura XR.

How Supplied:

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