Trospium Chloride Generic Name & Formulations
Trospium chloride 20mg; tabs.
Trospium Chloride Indications
Overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.
Trospium Chloride Dosage and Administration
Take on empty stomach. 20mg twice daily. ≥75yrs: 20mg once daily if twice daily dose not tolerated. Severe renal impairment (CrCl<30mL/min): 20mg once daily at bedtime.
Trospium Chloride Contraindications
Gastric or urinary retention; uncontrolled narrow-angle glaucoma; and patients at risk for these conditions.
Trospium Chloride Boxed Warnings
Trospium Chloride Warnings/Precautions
Bladder outflow obstruction. GI obstructive disorders. Ulcerative colitis. Narrow-angle glaucoma (monitor). Intestinal atony. Myasthenia gravis. Exposure to high environmental temperature. Renal insufficiency (CrCl 30–80mL/min). Moderate to severe hepatic dysfunction. Pregnancy (Cat.C). Nursing mothers.
Trospium Chloride Pharmacokinetics
Trospium Chloride Interactions
Additive anticholinergic effects with other anticholinergics. Increased drowsiness with alcohol; avoid consumption within 2hrs of administration. May alter absorption of other drugs (decreased GI motility). May potentiate or be potentiated by drugs eliminated by active tubular secretion. May be antagonized by metformin.
Trospium Chloride Adverse Reactions
Anticholinergic effects (dry mouth, constipation, dry eyes, urinary retention, blurred vision), CNS effects (monitor), dyspepsia, headache.
Trospium Chloride Clinical Trials
Trospium Chloride Note
Formerly known under the brand name Sanctura, Sanctura XR.
Trospium Chloride Patient Counseling