• Pituitary disorders

Triptodur Generic Name & Formulations

General Description

Triptorelin pamoate 22.5mg; lyophilized microgranules for ext-rel IM inj after reconstitution; contains mannitol.

Pharmacological Class

GnRH agonist.

How Supplied

Single-use kit—1

Generic Availability


Triptodur Indications


Central precocious puberty.

Triptodur Dosage and Administration


Not applicable.


<2yrs: not established. Give as IM inj in buttock or thigh. ≥2yrs: 22.5mg once every 24 weeks. Discontinue at appropriate time point for onset of puberty. Consider switching to alternative GnRH agonist if Triptodur dose is inadequate.

Triptodur Contraindications



Triptodur Boxed Warnings

Not Applicable

Triptodur Warnings/Precautions


Use aseptic technique. Must be administered by a healthcare provider. Initial transient rise in gonadotropins and sex steroids may result in increased signs/symptoms of puberty. Monitor LH and sex steroid levels at 1–2 months after treatment initiation, during, and with each subsequent dose. Measure height every 3–6 months and bone age periodically. Monitor for pseudotumor cerebri or psychiatric symptoms. History of seizures/epilepsy, cerebrovascular disorders, CNS anomalies or tumors: risk of convulsions. Renal or hepatic impairment. Discontinue if overdosage occurs. Nursing mothers.

Triptodur Pharmacokinetics


Renal, hepatic.

Triptodur Interactions


Concomitant hyperprolactinemic drugs: not recommended. Caution with concomitant drugs that are associated with convulsions (eg, bupropion, SSRIs). May interfere with pituitary gonadotropic and gonadal function tests.

Triptodur Adverse Reactions

Adverse Reactions

Inj site reactions, menstrual bleeding, hot flush, headache, cough, infections (eg, bronchitis, gastroenteritis, influenza, nasopharyngitis, otitis externa, pharyngitis, sinusitis, upper respiratory tract infection).

Triptodur Clinical Trials

See Literature

Triptodur Note

Not Applicable

Triptodur Patient Counseling

See Literature