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Triostat Generic Name & Formulations
Legal Class
Rx
General Description
Liothyronine (as sodium) 10mcg/mL; soln for IV inj.
Pharmacological Class
T3 (synthetic).
How Supplied
Vials (1mL)—6
Manufacturer
Triostat Indications
Indications
Myxedema coma/precoma.
Triostat Dosage and Administration
Adult
Give with glucocorticoids. Allow 4–12 hours between doses. Initially 25–50mcg. Cardiovascular disease: initially 10–20mcg. Usual range: 65–100mcg daily. Change to oral therapy as soon as possible: start tabs at low dose and increase gradually; discontinue IV gradually.
Children
Not recommended.
Triostat Contraindications
Contraindications
Uncorrected adrenocortical insufficiency. Untreated thyrotoxicosis. Artificial rewarming.
Triostat Boxed Warnings
Boxed Warning
Not for treatment of obesity for weight loss.
Triostat Warnings/Precautions
Warnings/Precautions
Ineffective for weight reduction in euthyroid patients. Not for treatment of infertility. Cardiovascular disease, angina, elderly: initiate therapy at 10–20micrograms. Severe and prolonged hypothyroidism. Fluid therapy. Adrenocortical insufficiency. Pregnancy (Cat.A). Nursing mothers.
Triostat Pharmacokinetics
See Literature
Triostat Interactions
Interactions
Potentiates digitalis toxicity, tricyclic antidepressants, sympathomimetics (eg, anorectics). May increase risk of coronary insufficiency with vasopressors. Monitor oral anticoagulants, hypoglycemics. Estrogens affect thyroid function tests. May be potentiated by tricyclic antidepressants. Hypertension, tachycardia with ketamine.
Triostat Adverse Reactions
Adverse Reactions
Arrhythmia, tachycardia, cardiopulmonary arrest, hypotension, MI, angina, CHF, hypertension, twitching.
Triostat Clinical Trials
See Literature
Triostat Note
Not Applicable
Triostat Patient Counseling
See Literature
