• Thyroid disease

Triostat Generic Name & Formulations

General Description

Liothyronine (as sodium) 10mcg/mL; soln for IV inj.

Pharmacological Class

T3 (synthetic).

How Supplied

Vials (1mL)—6

Triostat Indications


Myxedema coma/precoma.

Triostat Dosage and Administration


Give with glucocorticoids. Allow 4–12 hours between doses. Initially 25–50mcg. Cardiovascular disease: initially 10–20mcg. Usual range: 65–100mcg daily. Change to oral therapy as soon as possible: start tabs at low dose and increase gradually; discontinue IV gradually.


Not recommended.

Triostat Contraindications


Uncorrected adrenocortical insufficiency. Untreated thyrotoxicosis. Artificial rewarming.

Triostat Boxed Warnings

Boxed Warning

Not for treatment of obesity for weight loss.

Triostat Warnings/Precautions


Ineffective for weight reduction in euthyroid patients. Not for treatment of infertility. Cardiovascular disease, angina, elderly: initiate therapy at 10–20micrograms. Severe and prolonged hypothyroidism. Fluid therapy. Adrenocortical insufficiency. Pregnancy (Cat.A). Nursing mothers.

Triostat Pharmacokinetics

See Literature

Triostat Interactions


Potentiates digitalis toxicity, tricyclic antidepressants, sympathomimetics (eg, anorectics). May increase risk of coronary insufficiency with vasopressors. Monitor oral anticoagulants, hypoglycemics. Estrogens affect thyroid function tests. May be potentiated by tricyclic antidepressants. Hypertension, tachycardia with ketamine.

Triostat Adverse Reactions

Adverse Reactions

Arrhythmia, tachycardia, cardiopulmonary arrest, hypotension, MI, angina, CHF, hypertension, twitching.

Triostat Clinical Trials

See Literature

Triostat Note

Not Applicable

Triostat Patient Counseling

See Literature