• Anemias

Triferic Generic Name & Formulations

General Description

Elemental iron (III) (as ferric pyrophosphate citrate) 5.44mg/mL soln; or 272mg per pwd pkt; for hemodialysis use.

Pharmacological Class


See Also

How Supplied

Ampules (5mL)—5, 40; (50mL)—4, 24; Single-dose ampules (4.5mL)—10, 40; Packets— 1, 100


Generic Availability


Triferic Indications


Iron replacement to maintain hemoglobin in adults with hemodialysis-dependent chronic kidney disease (HDD-CKD).

Limitations of Use

Not for use in patients receiving peritoneal dialysis. Not studied in patients receiving home hemodialysis.

Triferic Dosage and Administration


See full labeling. Must add soln (5mL or 50mL amp) or pwd (1 pkt) to bicarbonate concentrate (2.5 or 25gallons) for generation of hemodialysate. Final concentration (Triferic/in hemodialysate): 2micromolar (100mcg/L). Administer at each dialysis procedure.


Not established.

Triferic Contraindications

Not Applicable

Triferic Boxed Warnings

Not Applicable

Triferic Warnings/Precautions


Monitor for hypersensitivity reactions during and after hemodialysis until clinically stable. Have personnel and resuscitative equipment immediately available. Determine iron status on pre-dialysis blood samples. Pregnancy. Advise females of reproductive potential to use effective contraception during and for at least 2weeks after therapy completion. Nursing mothers.

Triferic Pharmacokinetics

See Literature

Triferic Interactions

Triferic Adverse Reactions

Adverse Reactions

Headache, peripheral edema, asthenia, AV fistula thrombosis, urinary tract infection, AV fistula site hemorrhage, pyrexia, fatigue, procedural hypotension, muscle spasms, pain in extremity, back pain, dyspnea.

Triferic Clinical Trials

See Literature

Triferic Note

Not Applicable

Triferic Patient Counseling

See Literature