• Pigmentation disorders

Tri-luma Generic Name & Formulations

General Description

Hydroquinone 4%, fluocinolone acetonide 0.01%, tretinoin 0.05%; crm; contains sulfites, parabens.

Pharmacological Class

Skin depigmenting agent + topical steroid + retinoid.

How Supplied


Tri-luma Indications


Short-term intermittent treatment of moderate to severe melasma of the face, with measures for sun avoidance including sunscreen use (SPF 30).

Tri-luma Dosage and Administration


Clean (use a mild, soap-free cleanser) and dry skin. Apply a thin film to affected area(s) and to ½ inch of surrounding normal skin once daily, at least 30 minutes before bedtime.


Not recommended.

Tri-luma Contraindications

Not Applicable

Tri-luma Boxed Warnings

Not Applicable

Tri-luma Warnings/Precautions


Do not occlude or use on eczema or sunburned skin. Avoid eyes, ears, mouth, angle of nose, mucous membranes, sun, UV light. Skin types V and VI (possible undesirable excessive bleaching). Discontinue if ochronosis, chemical irritation, hypersensitivity, or HPA axis suppression occurs. Increased irritation in extreme weather. Elderly. Pregnancy (Cat.C), nursing mothers: consider delaying use until after pregnancy/nursing.

Tri-luma Pharmacokinetics

See Literature

Tri-luma Interactions


Avoid photosensitizers, topical irritants, and drying agents.

Tri-luma Adverse Reactions

Adverse Reactions

Local irritation (erythema, peeling, burning, dryness, pruritus), acne, paresthesia, telangiectasia, hyperesthesia, folliculitis, dermatitis, secondary infection, hypertrichosis, skin atrophy, striae, miliaria, HPA axis suppression.

Tri-luma Clinical Trials

See Literature

Tri-luma Note

Not Applicable

Tri-luma Patient Counseling

See Literature