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Trecator Generic Name & Formulations
Legal Class
Rx
General Description
Ethionamide 250mg; tabs.
How Supplied
Tabs—100
Manufacturer
Trecator Indications
Indications
Adjunct in tuberculosis, when INH and rifampin are not appropriate.
Trecator Dosage and Administration
Adult
Give with meals to minimize GI upset. Initially 250mg/day in 1–4 divided doses; titrate to highest tolerated dose (see full labeling). Usual range: 15–20mg/kg daily; max 1g/day.
Children
Give with meals to minimize GI upset. 10–20mg/kg in 2–3 divided doses, or 15mg/kg once daily.
Trecator Contraindications
Contraindications
Severe hepatic impairment.
Trecator Boxed Warnings
Not Applicable
Trecator Warnings/Precautions
Warnings/Precautions
Confirm presence of susceptible bacterial infection before initiating therapy. Re-titrate when switching from Trecator SC sugar-coated tabs. Give with pyridoxine. Diabetes. Do baseline and periodic blood glucose levels, eye exams (including ophthalmoscopy). Monitor thyroid function. Obtain SGOT and SGPT before and monthly; suspend if levels increase. Pregnancy (Cat.C). Nursing mothers.
Trecator Pharmacokinetics
See Literature
Trecator Interactions
Interactions
Avoid alcohol. Potentiates other antituberculars. Convulsions with cycloserine.
Trecator Adverse Reactions
Adverse Reactions
GI upset, abdominal pain, excessive salivation, metallic taste, stomatitis, anorexia, liver dysfunction, psychosis, drowsiness, dizziness, restlessness, headache, postural hypotension, hypoglycemia, gynecomastia, impotence, acne; rarely; peripheral/optic neuritis, visual disturbances, pellagra, thrombocytopenia.
Trecator Clinical Trials
See Literature
Trecator Note
Notes
Trecator tablets have been reformulated from a sugar-coated tablet to a film-coated tablet which may result in higher peak levels.
Trecator Patient Counseling
See Literature
