Viral infections:

Indications for TPOXX:

Human smallpox disease caused by variola virus in patients weighing ≥13kg.

Limitations of Use:

Efficacy in humans has not been determined. Efficacy may be reduced in immunocompromised patients.

Adults and Children:

Take within 30mins after a moderate or high fat meal. If difficulty swallowing, may open capsule and mix contents in 30mL of liquid or soft food (eg, milk, apple sauce, yogurt); consume entire mixture. 13–<25kg: 200mg twice daily; 25–<40kg: 400mg twice daily; ≥40kg: 600mg twice daily. All: treat for 14 days.


Pregnancy. Nursing mothers.

Pharmacologic Class:



May potentiate repaglinide; monitor for hypoglycemia. May antagonize midazolam; monitor efficacy.

Adverse Reactions:

Headache, nausea, abdominal pain, vomiting.

Generic Availability:


How Supplied: