Overactive bladder/enuresis:

Indications for TOVIAZ:

Overactive bladder (OAB) with urge urinary incontinence, urgency, and frequency.

Adult Dosage:

Swallow whole with liquid. 4mg once daily; may increase to max 8mg once daily. Severe renal impairment (CrCl<30mL/min) or concomitant potent CYP3A4 inhibitors: max 4mg/day.

Children Dosage:

Not established.

TOVIAZ Contraindications:

Urinary or gastric retention. Uncontrolled narrow angle glaucoma.

TOVIAZ Warnings/Precautions:

Severe hepatic impairment: not recommended. Bladder outlet obstruction. Decreased GI motility (eg, severe constipation). Controlled narrow-angle glaucoma. Myasthenia gravis. Monitor for CNS effects esp. after initiation or dose increases; consider reducing dose or discontinue if occurs. Renal or hepatic impairment. Exposure to high environmental temperatures. Pregnancy. Nursing mothers.

TOVIAZ Classification:

Muscarinic antagonist.

TOVIAZ Interactions:

Potentiated by potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin); see Adult. Additive effects with other antimuscarinic or anticholinergic agents.

Adverse Reactions:

Dry mouth, constipation, urinary retention/UTI, dyspepsia, dry eyes; angioedema (discontinue if occurs), CNS effects (eg, headache, dizziness, somnolence).


Hepatic (CYP2D6, CYP3A4).

Drug Elimination:

Renal (primarily), fecal.

Generic Drug Availability:


How Supplied:


Pricing for TOVIAZ

8mg tablet (Qty: 30)
Appx. price $367