Tolmetin 600mg Generic Name & Formulations
Tolmetin sodium 600mg; tabs; contains sodium 54mg/tab.
Tolmetin 600mg Indications
Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. Treatment of acute flares and the long-term management of the chronic disease. Treatment of juvenile rheumatoid arthritis.
Tolmetin 600mg Dosage and Administration
Initially 400mg 3 times daily. Maintenance: 600–1800mg daily in divided doses; max 1800mg/day.
<2yrs: not recommended. ≥2yrs: Initially 20mg/kg/day in divided doses (3–4 times daily). Maintenance: usual dose range: 15–30mg/kg/day; max 30mg/kg/day.
Tolmetin 600mg Contraindications
Aspirin allergy. Coronary artery bypass graft surgery.
Tolmetin 600mg Boxed Warnings
Tolmetin 600mg Warnings/Precautions
Advanced renal disease: not recommended. Hypertension; monitor. CHF. Edema. Asthma. History of ulcer disease or GI bleeding. Bleeding disorders. Dehydration. Monitor blood, hepatic, and renal function in chronic use. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat. C: <30 weeks gestation; Cat. D: ≥30 weeks gestation: avoid). Nursing mothers: not recommended.
Tolmetin 600mg Pharmacokinetics
Tolmetin 600mg Interactions
Avoid aspirin. May antagonize ACE inhibitors, diuretics. Increased risk of GI bleed with oral corticosteroids, anticoagulants (monitor), alcohol, smoking. Methotrexate excretion reduced. Increases lithium levels.
Tolmetin 600mg Adverse Reactions
GI upset, abdominal pain, dyspepsia, flatulence, headache, asthenia, elevated BP, edema, dizziness, weight gain, weight loss; rash (discontinue if occurs), GI ulcer/bleed, elevated liver enzymes (discontinue if hepatotoxicity develops), blood dyscrasias, renal papillary necrosis. See literature re: risk of cardiovascular events.
Tolmetin 600mg Clinical Trials
Tolmetin 600mg Note
Formerly known under the brand name Tolectin 600.
Tolmetin 600mg Patient Counseling